6-(1-PYRROLIDINYL)HEXYLAMINE

Base Information

• Chemical Name: 6-(1-PYRROLIDINYL)HEXYLAMINE
• CAS No.: 2669-16-1
• Molecular Formula: C₁₀H₂₂N₂
• Molecular Weight: 170.298
• Mol file: 2669-16-1.mol

Synonyms:6-(pyrrolidine-1-yl)hexan-1-amine

Chemical Property of 6-(1-PYRROLIDINYL)HEXYLAMINE

Chemical Property:

Purity/Quality:

6-(Pyrrolidin-1-yl)hexan-1-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(1-PYRROLIDINYL)HEXYLAMINE

There total 10 articles about 6-(1-PYRROLIDINYL)HEXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(6-(pyrrolidin-1-yl)hexyl)isoindoline-1,3-dione → 6-(pyrrolidine-1-yl)hexan-1-amine (2669-16-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; Reflux;

DOI:10.1021/acs.jmedchem.9b01012

Reference yield:

1 ,6-dibromohexane (629-03-8) → 6-(pyrrolidine-1-yl)hexan-1-amine (2669-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / Reflux

2: potassium carbonate / acetone / 6 h / Reflux

3: hydrazine hydrate / ethanol / 20 °C

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1016/j.ejmech.2016.06.022

Reference yield:

6-Amino-1-pyrrolidin-1-yl-hexan-1-one (97124-81-7) → 6-(pyrrolidine-1-yl)hexan-1-amine (2669-16-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jm00390a011

upstream raw materials:

1,4-dibromo-butane

1,6-Hexanediamine

1,4-dichlorobutane

6-Amino-1-pyrrolidin-1-yl-hexan-1-one

Refernces

• 1、 Patel, Dushyant V.,Patel, Nirav R.,Kanhed, Ashish M.,Patel, Sagar P.,Sinha, Anshuman,Kansara, Deep D.,Mecwan, Annie R.,Patel, Sarvangee B.,Upadhyay, Pragnesh N.,Patel, Kishan B.,Shah, Dharti B.,Prajapati, Navnit K.,Murumkar, Prashant R.,Patel, Kirti V.,Yadav, Mange Ram. "Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents". . p. 3635 - 3661. Retrieved 2019/08/20.
• 2、 -. "SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS". . . Retrieved 2008/06/13.