2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine

Base Information

• Chemical Name: 2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine
• CAS No.: 4425-06-3
• Molecular Formula: C₁₇H₁₇FN₄O₅
• Molecular Weight: 376.344
• Mol file: 4425-06-3.mol

Synonyms:2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine

Chemical Property of 2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine

There total 6 articles about 2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-6-benzyloxy-9-β-D-ribofuranosylpurine (4552-61-8) → 2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine (4425-06-3)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; In water;

DOI:10.1139/v01-179

Reference yield:

2-Amino-6-chloropurine riboside (2004-07-1) → 2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine (4425-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: phenylmethanol

2: sodium nitrite; HBF₄ / H₂O

With tetrafluoroboric acid; sodium nitrite; In water; benzyl alcohol;

DOI:10.1139/v01-179

Reference yield:

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (16321-99-6) → 2-fluoro-6-benzyloxy-9-β-D-ribofuranosylpurine (4425-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₃ / methanol

2: phenylmethanol

3: sodium nitrite; HBF₄ / H₂O

With tetrafluoroboric acid; ammonia; sodium nitrite; In methanol; water; benzyl alcohol;

DOI:10.1139/v01-179

upstream raw materials:

2-amino-6-benzyloxy-9-β-D-ribofuranosylpurine

2-Amino-6-chloropurine riboside

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

G

Downstream raw materials:

2-dimethylamino-6-benzyloxy-9-β-D-ribofuranosylpurine

N₂,N₂-dimethylguanosine

Refernces