(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate

Base Information

• Chemical Name: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate
• CAS No.: 61548-81-0
• Molecular Formula: C₁₁H₂₂O₃S
• Molecular Weight: 234.36
• Mol file: 61548-81-0.mol

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate

Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate

There total 3 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(-)-menthol (2216-51-5) + methanesulfonyl chloride (124-63-0) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate (61548-81-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4ob02440k

Reference yield: 95.0%

menthol (15356-70-4) + methanesulfonyl chloride (124-63-0) → 2‐isopropyl‐5‐methylcyclohexyl methanesulfonate (61548-81-0,133617-15-9,142921-58-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chir.23156

Reference yield:

methane sulfonyl chloride + (-)-menthol (2216-51-5) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate (61548-81-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; water;

upstream raw materials:

menthol

methanesulfonyl chloride

(-)-menthol

Downstream raw materials:

(1R)-trans-p-menth-2-ene

L-menthyl acetate

(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl formate

(1S,2S,4R)-2-azido-1-isopropyl-4-methylcyclohexane

Refernces

• 1、 Abás, Sònia,Escolano, Carmen,Galdeano, Carles,Pujol, Eugènia,Rodríguez-Arévalo, Sergio,Vázquez, Santiago. "Synthesis, characterization and hplc analysis of the (1S,2S,5R)-diastereomer and the enantiomer of the clinical candidate ar-15512". . . Retrieved 2021/06/12.
• 2、 Wappes, Ethan A.,Fosu, Stacy C.,Chopko, Trevor C.,Nagib, David A.. "Triiodide-Mediated δ-Amination of Secondary C?H Bonds". supporting information. p. 9974 - 9978. Retrieved 2016/08/16.