1-[2-(4-methylphenyl)ethyl]urea

Base Information

• Chemical Name: 1-[2-(4-methylphenyl)ethyl]urea
• CAS No.: 25017-30-5
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.234
• Mol file: 25017-30-5.mol

Synonyms:Urea,(p-methylphenethyl)- (8CI); Urea, [2-(4-methylphenyl)ethyl]- (9CI)

Chemical Property of 1-[2-(4-methylphenyl)ethyl]urea

Chemical Property:

• Vapor Pressure: 0.000412mmHg at 25°C
• Boiling Point: 316.4°Cat760mmHg
• Flash Point: 145.1°C
• Density: 1.082g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(4-methylphenyl)ethyl]urea

There total 2 articles about 1-[2-(4-methylphenyl)ethyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-Methylphenethylamine hydrochloride (39260-86-1) + urea (57-13-6) → (2-p-Tolyl-ethyl)-urea (25017-30-5)

Guidance literature:

With hydrogenchloride; In water; for 3h; Heating;

DOI:10.1021/jm9508393

Reference yield:

→ (2-p-Tolyl-ethyl)-urea (25017-30-5)

Guidance literature:

/BRN= 223851/ (2b), H2, Pd/C, A. (Hydrogenolyse);

Reference yield:

(2-p-Tolyl-ethyl)-urea (25017-30-5) → 3-Carboxymethyl-1-(2-(4-methylphenyl)ethyl)parabanic acid

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / Ambient temperature

2: KOH / ethanol / 8 h / Heating

3: conc. HCl, AcOH / 4.5 h / Heating

With hydrogenchloride; potassium hydroxide; acetic acid; In tetrahydrofuran; ethanol;

DOI:10.1021/jm9508393

upstream raw materials:

p-Methylphenethylamine hydrochloride

urea

Downstream raw materials:

1-(2-p-Tolyl-ethyl)-imidazolidine-2,4,5-trione

ethyl 1-(2-(4-methylphenyl)ethyl)-2,4,5-trioxoimidazolidine-3-acetate

Refernces