C₂₅H₃₅NO₆S

Base Information

• Chemical Name: C₂₅H₃₅NO₆S
• CAS No.: 1352310-83-8
• Molecular Formula: C₂₅H₃₅NO₆S
• Molecular Weight: 477.622
• Mol file: 1352310-83-8.mol

Synonyms:C₂₅H₃₅NO₆S

Chemical Property of C₂₅H₃₅NO₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₅NO₆S

There total 12 articles about C₂₅H₃₅NO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

C44H67NO12S + (R)(+)-m-Metilsolfinil-anilina → C25H35NO6S (1352310-83-8)

Guidance literature:

C₄₄H₆₇NO₁₂S; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; In dichloromethane; at 20 ℃; for 0.25h;

(R)(+)-m-Metilsolfinil-anilina; In dichloromethane; for 36h;

Reference yield:

3(R,S)-(methylsulphinyl)aniline (39082-89-8,28295-53-6,28295-54-7,146451-09-4) + 3-(10-deoxoartemisin-10-yl)propanoic acid (508234-34-2) → C25H35NO6S (1352310-80-5) + C25H35NO6S (1352310-83-8)

Guidance literature:

3-(10-deoxoartemisin-10-yl)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

3(R,S)-(methylsulphinyl)aniline; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/jm201214d

Reference yield:

1-(methylsulfanyl)-3-nitrobenzene (2524-76-7) → C25H35NO6S (1352310-83-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; acetic acid / methanol; water / 24 h / 20 °C

2.1: chiral HPLC Regis Whelk-01 (S,S) / hexane; isopropyl alcohol / Resolution of racemate

3.1: hydrazine / methanol / 18 h

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 20 °C

4.2: 36 h

With dihydrogen peroxide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; In methanol; hexane; dichloromethane; water; isopropyl alcohol;

DOI:10.1021/jm201214d

upstream raw materials:

12β-(3'-hydroxy-n-propyl)-deoxoartemisinin

1-(methylsulfanyl)-3-nitrobenzene

methyl 3-nitrophenyl sulfoxide

3(R,S)-(methylsulphinyl)aniline

Refernces

• 1、 -. "MONOMERIC TRIOXANE AMIDE SULFUR COMPOUNDS". . . Retrieved 2012/11/06.