4'-t-butyl-2',6'-dimethylphenacyl bromide

Base Information

• Chemical Name: 4'-t-butyl-2',6'-dimethylphenacyl bromide
• CAS No.: 151427-08-6
• Molecular Formula: C₁₄H₁₉BrO
• Molecular Weight: 283.208
• Mol file: 151427-08-6.mol

Synonyms:4'-t-butyl-2',6'-dimethylphenacyl bromide

Chemical Property of 4'-t-butyl-2',6'-dimethylphenacyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-t-butyl-2',6'-dimethylphenacyl bromide

There total 1 articles about 4'-t-butyl-2',6'-dimethylphenacyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-tert-butyl-2,6-dimethylacetophenone (2040-10-0) → 4'-t-butyl-2',6'-dimethylphenacyl bromide (151427-08-6)

Guidance literature:

With bromine; In acetic acid; for 0.166667h;

Reference yield: 42.0%

potassium phtalimide (1074-82-4) + 4'-t-butyl-2',6'-dimethylphenacyl bromide (151427-08-6) → N-(4'-t-butyl-2',6'-dimethylphenacyl)phthalimide (151427-09-7)

Guidance literature:

In N,N-dimethyl-formamide; at 95 ℃; for 2h;

Reference yield:

4'-t-butyl-2',6'-dimethylphenacyl bromide (151427-08-6) → 5-(4-t-butyl-2,6-dimethylphenyl)-2-(4-pyridyl)oxazole (151426-95-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 42 percent / dimethylformamide / 2 h / 95 °C

2: 97 percent / KOH / H₂O; propan-1-ol / 3 h / Heating

3: 63 percent / 48percent HBr / acetic acid / 16 h / Heating

4: 48 percent / pyridine / 1 h / 70 °C

5: 29 percent / POCl₃ / Heating

With pyridine; potassium hydroxide; hydrogen bromide; trichlorophosphate; In propan-1-ol; water; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

4-tert-butyl-2,6-dimethylacetophenone

Downstream raw materials:

N-(4'-t-butyl-2',6'-dimethylphenacyl)phthalimide

5-(4-t-butyl-2,6-dimethylphenyl)-2-(4-pyridyl)oxazole

N-(4'-t-butyl-2',6'-dimethylphenacyl)isonicotinamide

N-<2-(4'-t-butyl-2',6'-dimethylphenyl)-2-oxoethyl>phthalamic acid

Refernces