alpha-Ketoglutarate

Base Information

• Chemical Name: alpha-Ketoglutarate
• CAS No.: 64-15-3
• Molecular Formula: C5H4O5
• Molecular Weight: 144.084
• DSSTox Substance ID: DTXSID80213974
• Nikkaji Number: J1.181.515D
• Wikidata: Q27102088
• Mol file: 64-15-3.mol

Synonyms:2 Ketoglutarate;2 Ketoglutaric Acid;2 Oxoglutarate;2 Oxoglutaric Acid;2-ketoglutarate;2-ketoglutaric acid;2-oxoglutarate;2-oxoglutaric acid;alpha Ketoglutarate;alpha Ketoglutaric Acid;alpha Ketoglutaric Acid, Diammonium Salt;alpha Ketoglutaric Acid, Dipotassium Salt;alpha Ketoglutaric Acid, Disodium Salt;alpha Ketoglutaric Acid, Monopotassium Salt;alpha Ketoglutaric Acid, Monosodium Salt;alpha Ketoglutaric Acid, Potassium Salt;alpha Ketoglutaric Acid, Sodium Salt;alpha Oxoglutarate;alpha-ketoglutarate;alpha-Ketoglutarate, Calcium;alpha-ketoglutaric acid;alpha-ketoglutaric acid, calcium salt (2:1);alpha-ketoglutaric acid, diammonium salt;alpha-ketoglutaric acid, dipotassium salt;alpha-ketoglutaric acid, disodium salt;alpha-ketoglutaric acid, monopotassium salt;alpha-ketoglutaric acid, monosodium salt;alpha-ketoglutaric acid, potassium salt;alpha-ketoglutaric acid, sodium salt;alpha-oxoglutarate;Calcium alpha Ketoglutarate;calcium alpha-ketoglutarate;calcium ketoglutarate;Ketoglutaric Acid;Ketoglutaric Acids;oxogluric acid;Oxoglutarates

Chemical Property of alpha-Ketoglutarate

Chemical Property:

• Boiling Point: 345.615 °C at 760 mmHg
• Flash Point: 177.02 °C
• Density: g/cm³
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 144.00587322
• Heavy Atom Count: 10
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)[O-])C(=O)C(=O)[O-]
• Recent ClinicalTrials: Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture

Technology Process of alpha-Ketoglutarate

There total 4 articles about alpha-Ketoglutarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-glutamate (154679-07-9,11070-68-1) + 4-methyloxovaleric acid anion (10250-86-9) → L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + α-ketoglutarate (64-15-3)

Guidance literature:

With pyridoxal 5-triphosphate; branched-chain-amino-acid transaminase from E_. coli; In phosphate buffer; at 298.15 ℃; pH=7.15 - 7.24; Product distribution; Thermodynamic data; Equilibrium constant; Enzymatic reaction;

DOI:10.1006/jcht.2000.0686

Reference yield:

α-ketoisovalerate (2507-77-9) + L-glutamate (154679-07-9,11070-68-1) → L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + α-ketoglutarate (64-15-3)

Guidance literature:

With pyridoxal 5-triphosphate; branched-chain-amino-acid transaminase from E_. coli; In phosphate buffer; at 298.15 ℃; pH=7.18 - 7.24; Product distribution; Thermodynamic data; Equilibrium constant; Enzymatic reaction;

DOI:10.1006/jcht.2000.0686

Reference yield:

L-Saccharopine (997-68-2) → L-lysine (56-87-1,3506-25-0) + α-ketoglutarate (64-15-3)

Guidance literature:

With Saccharomyces cerevisiae saccharopine dehydrogenase, molecular mass: 41 kDa; NAD; at 25 ℃; pH=7.2; Reagent/catalyst; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1074/jbc.M110.119826

upstream raw materials:

α-ketoisovalerate

L-glutamate

4-methyloxovaleric acid anion

L-Saccharopine

Downstream raw materials:

L-Saccharopine

ethene

oxaloacetate

L-glutamate

Refernces

• 1、 Tewari, Yadu B.,Goldberg, Robert N.,Rozzell, J. David. "Thermodynamics of reactions catalysed by branched-chain-amino-acid transaminase". . p. 1381 - 1398. Retrieved 2007/10/03.