Phosphinic acid, (4-methylphenyl)-

Base Information

• Chemical Name: Phosphinic acid, (4-methylphenyl)-
• CAS No.: 20783-50-0
• Molecular Formula: C7H9 O2 P
• Molecular Weight: 156.121
• DSSTox Substance ID: DTXSID40885151
• Wikidata: Q82863765
• Mol file: 20783-50-0.mol

Synonyms:20783-50-0;p-Tolylphosphinic acid;Phosphinic acid, (4-methylphenyl)-;Phosphinic acid, p-tolyl-;BRN 2802374;Phosphinic acid, P-(4-methylphenyl)-;Phosphinic acid,p-tolyl-;SCHEMBL230854;DTXSID40885151;AKOS006275047;LS-106212;4-16-00-01054 (Beilstein Handbook Reference)

Chemical Property of Phosphinic acid, (4-methylphenyl)-

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 60.77000
• Density: g/cm³
• LogP: 1.08730
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 155.02619149
• Heavy Atom Count: 10
• Complexity: 128

Purity/Quality:

(4-METHYLPHENYL)PHOSPHINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)[P+](=O)O

Technology Process of Phosphinic acid, (4-methylphenyl)-

There total 14 articles about Phosphinic acid, (4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

ethyl diethoxymethyl(4-methylphenyl)phosphinate → p-tolylphosphinic acid (20783-50-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 6h; Heating;

Reference yield:

2-p-tolyl-benzo[1,3,2]dioxaphosphole-2-oxide + water (7732-18-5) → p-tolylphosphinic acid (20783-50-0) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9)

Guidance literature:

Reference yield:

4-tolyl iodide (624-31-7) → p-tolylphosphinic acid (20783-50-0)

Guidance literature:

4-tolyl iodide; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; anilinium hypophosphite; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 120 ℃; Microwave irradiation; Inert atmosphere;

With sodium hydroxide; In diethyl ether; water;

With hydrogenchloride; In water;

DOI:10.1016/j.tet.2009.10.028

upstream raw materials:

ethanol

p-tolyldichlorophosphine

p-toluidine

water

Downstream raw materials:

4-fluorophenyl(4-tolyl)phosphinic acid

4-phosphonbenzoic acid

(4-methyl-3-nitro-phenyl)-phosphonic acid

4-methylphenylphosphine

Refernces

• 1、 Bennett, Stuart N. L.,Hall, Roger G.. "New syntheses of arylphosphinic acids from the reaction of ethyl diethoxymethylphosphinate with aryl bromides and phenols". . p. 1145 - 1152. Retrieved 2007/10/02.