Tris(4-fluorophenyl)phosphine

Base Information

• Chemical Name: Tris(4-fluorophenyl)phosphine
• CAS No.: 18437-79-1
• Molecular Formula: C18H12F3OP
• Molecular Weight: 332.262
• Hs Code.: 2903999090
• Mol file: 18437-79-1.mol

Synonyms:Phosphineoxide, tris(p-fluorophenyl)- (8CI);NSC 164997;Tris(4-fluorophenyl)phosphine oxide;Tris(p-fluorophenyl)phosphine oxide;1-Bis(4-fluorophenyl)phosphoryl-4-fluorobenzene;

Chemical Property of Tris(4-fluorophenyl)phosphine

Chemical Property:

• Vapor Pressure: 7.12E-08mmHg at 25°C
• Melting Point: 80-81℃
• Refractive Index: 1.58
• Boiling Point: 450.3 °C at 760 mmHg
• Flash Point: 226.1 °C
• PSA: 26.88000
• Density: 1.32 g/cm³
• LogP: 3.74330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tris(4-fluorophenyl)phosphine

There total 11 articles about Tris(4-fluorophenyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

P(p-C6H4F)3 (18437-78-0) → tri(4-fluorophenyl)phosphine oxide (18437-79-1)

Guidance literature:

With water; Selectfluor; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2016.06.078

Reference yield: 40.0%

tetrakis(hydroxymethyl)phosphonium chloride (124-64-1) + 1-Bromo-4-fluorobenzene (460-00-4) → tri(4-fluorophenyl)phosphine oxide (18437-79-1) + bis(4-fluorophenyl)methylphosphine oxide

Guidance literature:

With 3 A molecular sieve; potassium carbonate; [(o-Tol)2PC₆H₄CH₂Pd(OAc)]2; In N,N-dimethyl acetamide; at 130 ℃; for 17h;

DOI:10.1080/00397910008087212

Reference yield:

2,2,2-Tris-(4-fluoro-phenyl)-4,4,5,5-tetramethyl-2λ5-[1,3,2]dioxaphospholane (73116-93-5) → 2,3-dimethyl-2,3-epoxybutane (5076-20-0) + tri(4-fluorophenyl)phosphine oxide (18437-79-1)

Guidance literature:

In benzene-d6; at 38 ℃; Rate constant;

DOI:10.1021/jo01306a010

upstream raw materials:

2,2,2-Tris-(4-fluoro-phenyl)-4,4,5,5-tetramethyl-2λ⁵-[1,3,2]dioxaphospholane

P(p-C₆H₄F)3

tris(hydroxymethyl)phosphine

1-Bromo-4-fluorobenzene

Downstream raw materials:

(E)-[2-(1,2-diphenylethenyl)-4-fluorophenyl]bis(4-fluorophenyl)phosphine oxide

P(p-C₆H₄F)3

C₁₈H₁₂ClF₃P⁽¹⁺⁾*Cl^(1-)

Refernces

• 1、 Yasui, Shinro,Tojo, Sachiko,Majima, Tetsuro. "Effects of substituents on aryl groups during the reaction of triarylphosphine radical cation and oxygen". . p. 2969 - 2973. Retrieved 2006.
• 2、 Henyecz, Réka,Huszár, Bianka,Keglevich, Gy?rgy,Mucsi, Zoltán. "Microwave assisted P–C coupling reactions without directly added P-ligands". . . Retrieved 2021/12/24.
• 3、 -. "Organic long afterglow material with photoactivation characteristic as well as preparation method and application thereof". Paragraph 0050-0055. . Retrieved 2020/09/09.