1-(p-methoxyphenyl)pent-2-yne-1,4-diol

Base Information

• Chemical Name: 1-(p-methoxyphenyl)pent-2-yne-1,4-diol
• CAS No.: 135468-06-3
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 135468-06-3.mol

Synonyms:1-(p-methoxyphenyl)pent-2-yne-1,4-diol

Chemical Property of 1-(p-methoxyphenyl)pent-2-yne-1,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(p-methoxyphenyl)pent-2-yne-1,4-diol

There total 1 articles about 1-(p-methoxyphenyl)pent-2-yne-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-methoxyphenyl)-2-propyn-1-ol (19115-30-1) + acetaldehyde (75-07-0,9002-91-9) → 1-(p-methoxyphenyl)pent-2-yne-1,4-diol (135468-06-3)

Guidance literature:

1-(4-methoxyphenyl)-2-propyn-1-ol; With n-butyllithium; at -78 ℃; for 1h; Inert atmosphere;

acetaldehyde; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200900391

Reference yield: 97.0%

1-(p-methoxyphenyl)pent-2-yne-1,4-diol (135468-06-3) → 1-(4-methoxyphenyl)pentane-1,4-dione (2108-54-5)

Guidance literature:

With tributylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In acetonitrile; for 20h; Heating;

DOI:10.1021/jo00020a015

Reference yield: 64.0%

1-(p-methoxyphenyl)pent-2-yne-1,4-diol (135468-06-3) → 2-(4-methoxyphenyl)-5-methylbenzofuran (18476-67-0) + 1-(4-methoxyphenyl)pentane-1,4-dione (2108-54-5)

Guidance literature:

With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2009.06.108

upstream raw materials:

1-(4-methoxyphenyl)-2-propyn-1-ol

acetaldehyde

Downstream raw materials:

1-(4-methoxyphenyl)pentane-1,4-dione

2-(4-methoxyphenyl)-5-methylbenzofuran

C₁₆H₁₈O₅

Refernces