5-AMINO-2-METHOXYBENZOTRIFLUORIDE

Base Information

• Chemical Name: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
• CAS No.: 393-15-7
• Molecular Formula: C8H8F3NO
• Molecular Weight: 191.153
• Hs Code.: 2922299090
• Mol file: 393-15-7.mol

Synonyms:p-Anisidine,3-(trifluoromethyl)- (6CI,8CI);3-Amino-6-methoxybenzotrifluoride;4-(Methyloxy)-5-(trifluoromethyl)aniline;4-Methoxy-3-(trifluoromethyl)aniline;4-Methoxy-3-trifluoromethylphenylamine;4-Methoxy-5-trifluoromethylaniline;5-Amino-2-methoxybenzotrifluoride;

Chemical Property of 5-AMINO-2-METHOXYBENZOTRIFLUORIDE

Chemical Property:

• Appearance/Colour: Solid
• Vapor Pressure: 0.0226mmHg at 25°C
• Melting Point: 28 °C
• Refractive Index: 1.476
• Boiling Point: 112 °C
• PKA: 3.98±0.10(Predicted)
• Flash Point: 104.8 °C
• PSA: 35.25000
• Density: 1.28 g/cm³
• LogP: 2.87740
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

4-Methoxy-3-(trifluoromethyl)aniline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T,Xn
• Statements: 20/21/22-36/37/38-52-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-2-METHOXYBENZOTRIFLUORIDE

There total 8 articles about 5-AMINO-2-METHOXYBENZOTRIFLUORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methoxy-4-nitro-2-(trifluoromethyl)benzene (654-76-2) → 4-methoxy-3-(trifluoromethyl)aniline (393-15-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; water; at 20 ℃; for 3.5h; under 760.051 Torr;

Reference yield: 65.0%

4-bromo-1-methoxy-2-(trifluoromethyl)benzene (1514-11-0) → 4-methoxy-3-(trifluoromethyl)aniline (393-15-7)

Guidance literature:

4-bromo-1-methoxy-2-(trifluoromethyl)benzene; With magnesium; In tetrahydrofuran; Inert atmosphere;

With C₁₀H₁₇NO; In tetrahydrofuran; toluene; at -78 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; toluene; Inert atmosphere;

DOI:10.1038/nchem.2672

Reference yield:

1-methoxy-4-nitro-2-(trifluoromethyl)benzene (654-76-2) + iron (7439-89-6) → 4-methoxy-3-(trifluoromethyl)aniline (393-15-7)

Guidance literature:

With hydrogenchloride; In ethanol; water; ethyl acetate;

upstream raw materials:

1-methoxy-4-nitro-2-(trifluoromethyl)benzene

4-chloro-3-(trifluoromethyl)nitrobenzene

1-chloro-2-(trifluoromethyl)benzene

iron

Refernces

• 1、 Cheung, Chi Wai,Surry, David S.,Buchwald, Stephen L.. "Mild and highly selective palladium-catalyzed monoarylation of ammonia enabled by the use of bulky biarylphosphine ligands and palladacycle precatalysts". supporting information. p. 3734 - 3737. Retrieved 2013/08/23.
• 2、 Rahaim Jr., Ronald J.,Maleczka Jr., Robert E.. "Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates". . p. 3316 - 3340. Retrieved 2008/09/17.