5-(4-hydroxyphenyl)-γ-butyrolactone

Base Information

• Chemical Name: 5-(4-hydroxyphenyl)-γ-butyrolactone
• CAS No.: 14328-06-4
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.188
• Mol file: 14328-06-4.mol

Synonyms:5-(4-hydroxyphenyl)-γ-butyrolactone

Chemical Property of 5-(4-hydroxyphenyl)-γ-butyrolactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-hydroxyphenyl)-γ-butyrolactone

There total 6 articles about 5-(4-hydroxyphenyl)-γ-butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-(4-Methoxyphenyl)butyric acid (4521-28-2) → 5-(4-hydroxyphenyl)-γ-butyrolactone (14328-06-4)

Guidance literature:

With sodium persulfate; In water; Heating;

DOI:10.1081/SCC-100104057

Reference yield: 71.0%

3-(4-hydroxybenzoyl)propionic acid (56872-39-0) → 5-(4-hydroxyphenyl)-γ-butyrolactone (14328-06-4)

Guidance literature:

With sodium tetrahydroborate; calcium chloride; In methanol;

DOI:10.1021/jm801112u

Reference yield:

methoxybenzene (100-66-3) → 5-(4-hydroxyphenyl)-γ-butyrolactone (14328-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / AlCl₃ / nitrobenzene / 6 h / 20 °C

2: 71 percent / Zn; HgCl₂; aq. HCl / toluene / 40 h / Heating

3: 84 percent / CuCl₂*2H₂O; Na₂S₂O₈ / H₂O / Heating

With hydrogenchloride; sodium persulfate; aluminium trichloride; mercury dichloride; zinc; In water; nitrobenzene; toluene;

DOI:10.1081/SCC-100104057

upstream raw materials:

4-(4-Methoxyphenyl)butyric acid

methoxybenzene

4-(4-methoxy-phenyl)-4-oxo-butyric acid

3-(4-hydroxybenzoyl)propionic acid

Downstream raw materials:

(RS)-5-[4-(2-furylmethoxy)phenyl]dihydrofuran-2(3H)-one

(RS)-5-[4-(4-fluorobenzyloxy)phenyl]dihydrofuran-2(3H)-one

(RS)-5-[4-(4-bromobenzyloxy)phenyl]dihydrofuran-2(3H)-one

(RS)-5-[4-(4-iodobenzyloxy)phenyl]dihydrofuran-2(3H)-one

Refernces

• 1、 H?g, Signe,Wellendorph, Petrine,Nielsen, Birgitte,Frydenvang, Karla,Dahl, Ivar F.,Br?uner-Osborne, Hans,Brehm, Lotte,Fr?lund, Bente,Clausen, Rasmus P.. "Novel high-affinity and selective biaromatic 4-substituted γ-hydroxybutyric acid (GHB) analogues as GHB ligands: Design, synthesis, and binding studies". experimental part. p. 8088 - 8095. Retrieved 2009/12/07.
• 2、 Zymalkowski,Gelberg. "The reduction of beta-benzoyl-propionic acids of the resorcinol series". . p. 545 - 559. Retrieved 2007/10/05.