4-Bromo-3-nitrobenzoic acid

Base Information

• Chemical Name: 4-Bromo-3-nitrobenzoic acid
• CAS No.: 6319-40-0
• Molecular Formula: C7H4BrNO4
• Molecular Weight: 246.017
• Hs Code.: 29163990
• Mol file: 6319-40-0.mol

Synonyms:4-bromo-3-nitro-benzoate;Benzoic acid, 4-bromo-3-nitro-;4-bromo-3-nitro-benzoic acid;3-Nitro-4-bromobenzoic acid;

Chemical Property of 4-Bromo-3-nitrobenzoic acid

Chemical Property:

• Vapor Pressure: 3.22E-05mmHg at 25°C
• Melting Point: 202-204 °C
• Refractive Index: 1.6200 (estimate)
• Boiling Point: 340.9 °C at 760 mmHg
• PKA: 3.35±0.10(Predicted)
• Flash Point: 160 °C
• PSA: 83.12000
• Density: 1.892 g/cm³
• LogP: 2.57870
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-3-nitrobenzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-Bromo-3-nitrobenzoic acid

There total 10 articles about 4-Bromo-3-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Bromobenzoic acid (586-76-5) → 4-bromo-3-nitrobenzoic acid (6319-40-0)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃; for 5h;

DOI:10.3762/bjoc.12.219

Reference yield: 48.6%

4-Bromo-3-nitrotoluene (5326-34-1) → 4-bromo-3-nitrobenzoic acid (6319-40-0)

Guidance literature:

With pyridine; hydrogenchloride; potassium permanganate; In water;

Reference yield:

→ 4-bromo-3-nitrobenzoic acid (6319-40-0)

Guidance literature:

With sulfuric acid; nitric acid; at -5 ℃;

DOI:10.1039/jr9310002388

upstream raw materials:

4-Bromobenzoic acid

4-Bromo-3-nitrotoluene

4-bromo-3-nitrobenzaldehyde

sulfuric acid

Downstream raw materials:

4-bromo-3-nitrobenzoyl chloride

3-amino-4-bromobenzoic acid

2-nitrodiphenylamine-4-carboxylic acid

3-nitro-4-o-toluidino-benzoic acid

Refernces

• 1、 -. "BENZAMIDE OR BENZAMINE COMPOUNDS USEFUL AS ANTICANCER AGENTS FOR THE TREATMENT OF HUMAN CANCERS". Paragraph 0730; 0731; 0732. . Retrieved 2017/01/26.
• 2、 Klinkebiel, Arne,Beyer, Ole,Malawko, Barbara,Lüning, Ulrich. "Elongated and substituted triazine-based tricarboxylic acid linkers for MOFs". supporting information. p. 2267 - 2273. Retrieved 2016/11/17.