VitaMin D2 Tosylate

Base Information

• Chemical Name: VitaMin D2 Tosylate
• CAS No.: 72204-99-0
• Molecular Formula: C₃₅H₅₀O₃S
• Molecular Weight: 550.846
• Mol file: 72204-99-0.mol

Synonyms:Vitamin D₂ tosylate

Chemical Property of VitaMin D2 Tosylate

Chemical Property:

• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

Vitamin D2 Tosylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Protected Vitamin D2 (V676040), the synthetic form of Vitamin D. Used in the preparation of Vitamin D analogues. Protected Vitamin D2 (V676040), the synthetic form of Vitamin D. VitaMin D2 Tosylate is used in the preparation of Vitamin D analogues.

Technology Process of VitaMin D2 Tosylate

There total 2 articles about VitaMin D2 Tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Calciferol (50-14-6) + p-toluenesulfonyl chloride (98-59-9) → vitamin D2 p-toluenesulfonate (72204-99-0)

Guidance literature:

With pyridine;

DOI:10.1246/bcsj.67.2494

Reference yield:

Vitamin D2 (50-14-6) + p-toluenesulfonyl chloride (98-59-9) → Vitamin D2 tosylate (72204-99-0)

Guidance literature:

In pyridine; at 3 ℃; for 30h;

DOI:10.1021/jo01304a022

Reference yield: 50.2%

vitamin D2 p-toluenesulfonate (72204-99-0) → C28H43N3

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 45 ℃; Inert atmosphere;

upstream raw materials:

Vitamin D₂

p-toluenesulfonyl chloride

Calciferol

Downstream raw materials:

(6RS)-<6-methoxy-23,24-bisnor-9,10-seco-3,5-cyclochola-7,10(19)-dien-22-yl> phenyl sulfone

22-hydroxy-6,19-episulfono-23,24-bisnor-9,10-secochola-5(10),7-dien-3β-yl p-toluenesulfonate

(6RS)-6-methoxy-23,24-bisnor-9,10-seco-3,5-cyclochola-9,10⁽¹⁹⁾-dien-22-yl p-toluenesulfonate

Toluene-4-sulfonic acid (S)-3-[(1R,3aS,7aR)-7a-methyl-1-((S)-1-methyl-2-oxo-ethyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-yl ester

Refernces

• 1、 -. "Based on nitrogen heterocyclic modified vitamin D2 derivatives, synthesis and use". Paragraph 0021; 0024; 0025; 0026. . Retrieved 2017/08/25.
• 2、 -. "METHODS FOR PRODUCING PARICALCITOL". Page/Page column 100. . Retrieved 2010/04/03.