1-azido-4-methoxy-2-nitrobenzene

Base Information

• Chemical Name: 1-azido-4-methoxy-2-nitrobenzene
• CAS No.: 10336-13-7
• Molecular Formula: C₇H₆N₄O₃
• Molecular Weight: 194.15
• Mol file: 10336-13-7.mol

Synonyms:1-azido-4-methoxy-2-nitrobenzene

Chemical Property of 1-azido-4-methoxy-2-nitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-azido-4-methoxy-2-nitrobenzene

There total 5 articles about 1-azido-4-methoxy-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

concentrated hydrocholoric acid + 4-methoxy-2-nitroaniline (96-96-8) → 1-azido-4-methoxy-2-nitrobenzene (10336-13-7)

Guidance literature:

With sodium nitrite; In water;

Reference yield:

4-methoxy-aniline (104-94-9) → 1-azido-4-methoxy-2-nitrobenzene (10336-13-7)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 0.25 h / Heating

2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min

3: conc. sulfuric acid / 0.25 h / 100 °C

4: 1.) aq. HCl, NaNO₂, 2.) aq. NaN₃, sodium acetate / 1.) 0 deg C, 15 min

With hydrogenchloride; sodium azide; sulfuric acid; nitric acid; sodium acetate; sodium nitrite; In acetic acid;

DOI:10.1021/jm00010a023

Reference yield:

2-chloro-5-methoxynitrobenzene (10298-80-3) → 1-azido-4-methoxy-2-nitrobenzene (10336-13-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/jhet.3395

upstream raw materials:

4-methoxy-2-nitroacetanilide

4-methoxyacetanilide

4-methoxy-aniline

4-methoxy-2-nitroaniline

Downstream raw materials:

(4-methoxy-2-nitro-phenyl)-(1,2,5-triphenyl-1H-1λ⁵-phosphol-1-ylidene)-amine

5-methoxy-benzo[1,2,5]oxadiazole 1-oxide

Refernces

• 1、 -. "Antimicrobial and anticollagenase activity of phenazine-5, 10-dioxide and derivatives". . . Retrieved 2008/06/13.