1-Piperideine

Base Information

• Chemical Name: 1-Piperideine
• CAS No.: 505-18-0
• Molecular Formula: C5H9 N
• Molecular Weight: 83.1332
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20198514
• Nikkaji Number: J102.014E
• Wikidata: Q27104595
• Metabolomics Workbench ID: 52467
• Mol file: 505-18-0.mol

Synonyms:1-piperideine;1-piperideine hydrochloride;1-piperideine hydrochloride, 2-(14)C-labeled;1-piperideine, 2-(14)C-labeled;2,3,4,5,-tetrahydropyridine

Chemical Property of 1-Piperideine

Chemical Property:

• Vapor Pressure: 8.07mmHg at 25°C
• Melting Point: 60.50 °C
• Boiling Point: 139.2°Cat760mmHg
• PKA: 7.46±0.20(Predicted)
• Flash Point: 29.1°C
• PSA: 12.36000
• Density: 0.93g/cm³
• LogP: 0.67670
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 83.073499291
• Heavy Atom Count: 6
• Complexity: 57

Purity/Quality:

99%, ^*data from raw suppliers

Piperideine,trimer 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN=CC1
• Uses: 1-Piperideine can be used as metabolic biomarkers for human oral cancer detection.

Technology Process of 1-Piperideine

There total 47 articles about 1-Piperideine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-chloropiperidine (2156-71-0) → 2,3,4,5-tetrahydropyridine (505-18-0)

Guidance literature:

With potassium hydroxide; at 80 ℃; for 3h; under 0.001 Torr;

DOI:10.1016/S0040-4020(01)86146-9

Reference yield: 69.0%

piperidine (110-89-4) → 2,3,4,5-tetrahydropyridine (505-18-0)

Guidance literature:

piperidine; With N-chloro-succinimide; In diethyl ether; at 0 - 20 ℃; for 3.5h;

With sodium methylate; In methanol; diethyl ether; for 1h; Reflux;

DOI:10.1002/chem.201504845

Reference yield: 65.0%

1,5-diazidopentane (17607-21-5) → 2,3,4,5-tetrahydropyridine (505-18-0)

Guidance literature:

With benzyltriethylammonium tetrathiomolybdate; In water; acetonitrile; at 25 ℃; for 8h;

DOI:10.1021/jo00128a048

upstream raw materials:

Tripiperidin

tetradecahydro-tripyrido[1,2-a;1',2'-c;3'',2''-e]pyrimidine

(E)-1-(phenyldiazenyl)piperidine

1,5-diaminopentane

Downstream raw materials:

meso-1,3-di-piperidin-2-yl-propan-2-one

racem.-1,3-di-[2]piperidyl-acetone

isopelletierine

1,2,3,4,5,6,3',4',5',6'-decahydro-[2,3']bipyridinyl

Refernces

• 1、 Massa, Silvia,Spano, Delia,Pintus, Francesca,Medda, Rosaria,Floris, Giovanni. "Oxidation of di- and polyamines: In vitro effect of amino aldehydes on the vitality of Leishmania promastigotes". . p. 77 - 83. Retrieved 2010.
• 2、 Sun, Jieyin,Morita, Hiroyuki,Abe, Ikuro,Noguchi, Hiroshi,Chen, Guoshen. "Molecular cloning and characterization of copper amine oxidase from Huperzia serrata". . p. 5784 - 5790,7. Retrieved 2012.
• 3、 Paul, Anirudra,Kim, Jae Hyun,Daniel, Scott D.,Seidel, Daniel. "Diversification of Unprotected Alicyclic Amines by C?H Bond Functionalization: Decarboxylative Alkylation of Transient Imines". supporting information. p. 1625 - 1628. Retrieved 2020/11/30.
• 4、 Chen, Weijie,Seidel, Daniel. "α-C-H/N-H Annulation of Alicyclic Amines via Transient Imines: Preparation of Polycyclic Lactams". supporting information. p. 3729 - 3734. Retrieved 2021/05/31.