inner salt of ethoxy combretastatin phosphorylcholine

Base Information

• Chemical Name: inner salt of ethoxy combretastatin phosphorylcholine
• CAS No.: 1015697-62-7
• Molecular Formula: C₂₄H₃₄NO₈P
• Molecular Weight: 495.51
• Mol file: 1015697-62-7.mol

Synonyms:inner salt of ethoxy combretastatin phosphorylcholine

Chemical Property of inner salt of ethoxy combretastatin phosphorylcholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of inner salt of ethoxy combretastatin phosphorylcholine

There total 2 articles about inner salt of ethoxy combretastatin phosphorylcholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C21H25O8P (1015697-73-0) + trimethylamine (75-50-3) → inner salt of ethoxy combretastatin phosphorylcholine (1015697-62-7)

Guidance literature:

In water; acetonitrile; at 20 ℃; for 20h;

Reference yield:

(Z)-2-ethoxy-5-(3,4,5-trimethoxystyryl)phenol (1015697-59-2) + 2-Chloro-2-oxo-1,3,2-dioxaphospholane (6609-64-9) + trimethylamine (75-50-3) → inner salt of ethoxy combretastatin phosphorylcholine (1015697-62-7)

Guidance literature:

(Z)-2-ethoxy-5-(3,4,5-trimethoxystyryl)phenol; 2-Chloro-2-oxo-1,3,2-dioxaphospholane; With triethylamine; In benzene; at -40 - 20 ℃; for 10.5h;

trimethylamine; In water; acetonitrile; at 20 ℃; for 20h;

upstream raw materials:

C₂₁H₂₅O₈P

trimethylamine

(Z)-2-ethoxy-5-(3,4,5-trimethoxystyryl)phenol

2-Chloro-2-oxo-1,3,2-dioxaphospholane

Refernces

• 1、 -. "PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS". Page/Page column 9; fig.1. . Retrieved 2009/07/17.