N,N-Dimethyl-2-phenylacetamide

Base Information

• Chemical Name: N,N-Dimethyl-2-phenylacetamide
• CAS No.: 18925-69-4
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2924299090
• European Community (EC) Number: 621-404-9
• NSC Number: 406499
• UNII: XSG27XD6F9
• DSSTox Substance ID: DTXSID10172328
• Nikkaji Number: J82.811D
• Wikidata: Q83042430
• Mol file: 18925-69-4.mol

Synonyms:N,N-Dimethyl-2-phenylacetamide;18925-69-4;N,N-Dimethylphenylacetamide;N,N-Dimethylbenzeneacetamide;Benzeneacetamide, N,N-dimethyl-;Phenyl-N,N-dimethylacetamide;Acetamide, N,N-dimethyl-2-phenyl-;Phenylacetic acid N,N-dimethylamide;NSC-406499;NSC 406499;AI3-03604;Acetamide, N,N-dimethyl-2-phenyl- (8CI);N,N-dimethyl-phenylacetamide;XSG27XD6F9;SCHEMBL339507;Acetamide,N-dimethyl-2-phenyl-;n,n-dimethyl-2-phenyl-acetamide;DTXSID10172328;N,N-Dimethyl-alpha-phenylacetamide;MFCD00157672;NSC406499;STK068586;AKOS003555709;NCGC00339683-01;AS-80661;CS-0448930;FT-0740678;AB01332025-02

Chemical Property of N,N-Dimethyl-2-phenylacetamide

Chemical Property:

• Vapor Pressure: 0.00483mmHg at 25°C
• Boiling Point: 276.3°C at 760 mmHg
• Flash Point: 121.3°C
• PSA: 20.31000
• Density: 1.022g/cm³
• LogP: 1.31730
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 148

Purity/Quality:

99%min ^*data from raw suppliers

N,N-Dimethyl-2-phenylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Aromatics (Nitrogen)
• Canonical SMILES: CN(C)C(=O)CC1=CC=CC=C1

Technology Process of N,N-Dimethyl-2-phenylacetamide

There total 46 articles about N,N-Dimethyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N-dimethyl-2,3,3-triphenylpropanamide → N,N-dimethyl-2-phenylacetamide (18925-69-4) + Diphenylmethane (101-81-5)

Guidance literature:

With 9,10-dihydroanthracene; In 1,3,5-trimethyl-benzene; at 300 ℃; for 5h; Kinetics; Thermodynamic data; homolytic thermolysis; various temp.; ΔG(excit.), ΔH(excit.), ΔS(excit.);

Reference yield: 99.0%

dimethyl amine (124-40-3) + benzeneacetic acid methyl ester (101-41-7) → N,N-dimethyl-2-phenylacetamide (18925-69-4)

Guidance literature:

With magnesium chloride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/S0040-4039(01)00079-X

Reference yield: 98.0%

N,N-dimethylammonium chloride (506-59-2) + phenylacetyl chloride (103-80-0) → N,N-dimethyl-2-phenylacetamide (18925-69-4)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo015829q

upstream raw materials:

phenylacetic acid

N,N-dimethylsulfamide

diphenyl N-dimethylamidophosphate

dimethyl amine

Downstream raw materials:

O-Methyl α-phenylselenoacetate

N,N-dimethyl 2,3-diphenyl propanamide

1-phenyl-2-hexanone

Dimethyl-((E)-2-phenyl-1-trimethylsilanyloxy-vinyl)-amine

Refernces

• 1、 Habibi, Hassan,Mansourinejhad, Sanam,Saberi, Dariush,Shadi, Ahmad. "One-pot synthesis of a highly disperse core-shell CuO-alginate nanocomposite and the investigation of its antibacterial and catalytic properties". . p. 199 - 211. Retrieved 2021/12/30.
• 2、 Shao, Wen,Besnard, Céline,Guénée, Laure,Mazet, Clément. "Ni-Catalyzed Regiodivergent and Stereoselective Hydroalkylation of Acyclic Branched Dienes with Unstabilized C(sp3) Nucleophiles". supporting information. p. 16486 - 16492. Retrieved 2020/10/26.