Multi-step reaction with 10 steps
1.1: hydrogen / palladium 10% on activated carbon / 2585.81 Torr
2.1: triethylamine / dichloromethane / 0.5 h / -20 °C
3.1: ethanol; water / 20 - 60 °C
4.1: hydrogenchloride; water / 0 °C / Reflux
5.1: thionyl chloride / 0 °C / Reflux
6.1: triethylamine / dichloromethane / 0 - 20 °C
7.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice
8.1: hydrogenchloride; water / 0 °C / Reflux
9.1: triethylamine / dichloromethane / 20 °C
10.1: 1,2,3-Benzotriazole / benzene / 18 h / Reflux; Inert atmosphere
10.2: 0 - 25 °C / Inert atmosphere
With
hydrogenchloride; 1,2,3-Benzotriazole; thionyl chloride; potassium tert-butylate; water; hydrogen; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; benzene;