Biolf-70

Base Information

• Chemical Name: Biolf-70
• CAS No.: 84222-47-9
• Molecular Formula: C23H24 Cl N5 O3
• Molecular Weight: 453.928
• Mol file: 84222-47-9.mol

Synonyms:Biolf 70

Chemical Property of Biolf-70

Chemical Property:

• Vapor Pressure: 5.63E-18mmHg at 25°C
• Boiling Point: 673.1°C at 760 mmHg
• Flash Point: 360.9°C
• PSA: 98.04000
• Density: 1.33g/cm³
• LogP: 3.76830
• Solubility.: Dichloromethane, Dimethyl Sulfoxide, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

9-[[2-Benzyloxy-1-(benzyloxymethyl)-ethoxy]-methyl]-6-chloroguanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Guanine derivative

Technology Process of Biolf-70

There total 1 articles about Biolf-70 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dibenzyloxy-2-(chloromethoxy)propane (74564-16-2) + 2-Amino-6-chloropurin (10310-21-1) → 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine (84222-47-9)

Guidance literature:

With ammonium sulfate; mercury(II) cyanide; 1,1,1,3,3,3-hexamethyl-disilazane; Yield given. Multistep reaction; 1.) 2 h, reflux; 2.) benzene, 3 h, reflux;

DOI:10.1139/v82-430

Reference yield: 98.0%

9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine (84222-47-9) → 9-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purin-2-ylamine (89419-22-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; sodium acetate; In ethanol; for 18h; under 2068.6 Torr; Ambient temperature;

DOI:10.1139/v84-039

Reference yield: 70.0%

9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine (84222-47-9) → 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine (82410-31-9)

Guidance literature:

With mercaptoethyl alcohol; water; sodium; In methanol; for 2.5h; Heating;

DOI:10.1139/v82-430

upstream raw materials:

1,3-dibenzyloxy-2-(chloromethoxy)propane

2-Amino-6-chloropurin

Downstream raw materials:

9-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purin-2-ylamine

9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine

ganciclovir

Refernces