H-D-LEU-NH2 HCL

Base Information

• Chemical Name: H-D-LEU-NH2 HCL
• CAS No.: 80970-09-8
• Molecular Formula: C6H14 N2 O . Cl H
• Molecular Weight: 166.651
• Hs Code.: 2924199090
• Mol file: 80970-09-8.mol

Synonyms:Pentanamide,2-amino-4-methyl-, monohydrochloride, (2R)- (9CI); Pentanamide,2-amino-4-methyl-, monohydrochloride, (R)-; (R)-Leucinamide hydrochloride; NSC206279

Chemical Property of H-D-LEU-NH2 HCL

Chemical Property:

• Appearance/Colour: white - off-white powder
• Melting Point: >/=220
• Boiling Point: 250.9°Cat760mmHg
• Flash Point: 105.6°C
• PSA: 69.11000
• Density: 0.98g/cm³
• LogP: 2.04770
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

D-Leucine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-D-Leu-NH2 HCl

Technology Process of H-D-LEU-NH2 HCL

There total 1 articles about H-D-LEU-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1,3-dicyano-5-isopropenyl-2-methyl-cyclohexylamino)-4-methyl-pentanoic acid amide → (2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + (R)-2-amino-4-methylpentanamide hydrochloride (80970-09-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 50 ℃; for 4h; pH=1; Title compound not separated from byproducts;

DOI:10.1002/ejoc.200600294

Reference yield: 90.0%

(R)-2-amino-4-methylpentanamide hydrochloride (80970-09-8) + 4-chlorobenzenesulfonyl chloride (98-60-2) → (R)-2-(4-chlorobenzensulfonylamino)-4-methylpentanoic acid amide (553619-61-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2012.09.057

Reference yield: 89.0%

(R)-2-amino-4-methylpentanamide hydrochloride (80970-09-8) + Moz-Phe-OBzl (137314-55-7) → Moz-Phe-D-Leu-NH2 (145126-22-3)

Guidance literature:

With triethylamine; In tert-butyl alcohol; at 35 ℃; for 2.5h; industrial alkaline protease alcalase;

DOI:10.1021/jo00051a052

Downstream raw materials:

N-CBZ-L-Tyr-D-LeuNH₂

Moz-Phe-D-Leu-NH₂

[(1S,2S,4R)-1-Benzyl-4-((R)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

(R)-2-amino-4-methylpentanamide

Refernces