Fluorooxaloacetic acid diethyl ester

Base Information

• Chemical Name: Fluorooxaloacetic acid diethyl ester
• CAS No.: 392-58-5
• Molecular Formula: C8H11FO5
• Molecular Weight: 206.171
• Mol file: 392-58-5.mol

Synonyms:diethyl 2-fluoro-3-oxobutanedioate;

Chemical Property of Fluorooxaloacetic acid diethyl ester

Chemical Property:

• Vapor Pressure: 0.0201mmHg at 25°C
• Refractive Index: 1.4203 (589.3 nm 25℃)
• Boiling Point: 120-122℃ (9 Torr)
• Flash Point: 103°C
• PSA: 69.67000
• Density: 1.209g/cm³
• LogP: 0.01980
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Diethyl 2-fluoro-3-oxosuccinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Fluorooxaloacetic acid diethyl ester

There total 1 articles about Fluorooxaloacetic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

ethyl 2-fluoroacetate (459-72-3) + oxalic acid diethyl ester (95-92-1) → Diethyl fluoroxaloacetate (392-58-5) + α,α'-difluorocitric triethyl ester (2728-90-7)

Guidance literature:

oxalic acid diethyl ester; With sodium ethanolate; In ethanol; for 0.25h; Cooling with ice;

ethyl 2-fluoroacetate; In ethanol; at 20 ℃; Cooling with ice;

DOI:10.1016/j.jfluchem.2011.07.006

Reference yield: 95.2%

Diethyl fluoroxaloacetate (392-58-5) → fluoromalonic acid diethyl ester (685-88-1)

Guidance literature:

at 500 ℃; under 18751.9 - 22502.3 Torr; Temperature; Pressure;

Reference yield: 70.0%

hydrogen ethyl malonate (1071-46-1) + Diethyl fluoroxaloacetate (392-58-5) → Triethyl-fluorcitrat (309-98-8)

Guidance literature:

With pyridine; Heating;

DOI:10.1016/j.jfluchem.2011.07.006

upstream raw materials:

ethyl 2-fluoroacetate

oxalic acid diethyl ester

Downstream raw materials:

fluoromalonic acid diethyl ester

4-Acetoxy-α-fluor-zimtsaeure-ethylester

2-Fluor-4-phenyl-penten-⁽²⁾-saeureaethylester

3-Acetoxy-α-fluor-zimtsaeure-ethylester

Refernces