5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide]

Base Information

• Chemical Name: 5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide]
• CAS No.: 1252573-64-0
• Molecular Formula: C₂₇H₂₃Cl₂N₇O₂S₂
• Molecular Weight: 612.563
• Mol file: 1252573-64-0.mol

Synonyms:5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide]

Chemical Property of 5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide]

There total 6 articles about 5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(p-chlorophenyl)-3-thiosemicarbazide (22814-92-2) + C13H11NO4 → 5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide] (1252573-64-0)

Guidance literature:

In ethanol; water; Reflux;

DOI:10.1248/cpb.58.208

Reference yield:

4-phthalimidobutyric acid (3130-75-4) → 5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide] (1252573-64-0)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / Reflux

2: potassium hydroxide / diethyl ether; water / 0.17 h

3: hydrogen bromide / water; tetrahydrofuran

4: dimethyl sulfoxide / 2 h / 80 °C

5: ethanol / 2 h / Reflux

With thionyl chloride; hydrogen bromide; dimethyl sulfoxide; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; water;

Reference yield:

1-diazo-5-phthalimido-2-pentanone (84461-00-7) → 5-phthalimido-2-oxopentaldehyde bis[4-(4-chlorophenyl)-3-thiosemicarbazide] (1252573-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide / water; tetrahydrofuran

2: dimethyl sulfoxide / 2 h / 80 °C

3: ethanol / 2 h / Reflux

With hydrogen bromide; dimethyl sulfoxide; In tetrahydrofuran; ethanol; water;

upstream raw materials:

4-(p-chlorophenyl)-3-thiosemicarbazide

phthalic anhydride

4-phthalimidobutyric acid

2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione

Refernces

• 1、 Yang, Ya-Jun,Zhao, Jing-Hua,Pan, Xian-Dao,Zhang, Pei-Cheng. "Synthesis and antiviral activity of phthiobuzone analogues". experimental part. p. 208 - 211. Retrieved 2010/08/06.