N-methyl-O-phenacylcarbamate ethylene acetal

Base Information

• Chemical Name: N-methyl-O-phenacylcarbamate ethylene acetal
• CAS No.: 1314096-76-8
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.255
• Mol file: 1314096-76-8.mol

Synonyms:N-methyl-O-phenacylcarbamate ethylene acetal

Chemical Property of N-methyl-O-phenacylcarbamate ethylene acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-O-phenacylcarbamate ethylene acetal

There total 2 articles about N-methyl-O-phenacylcarbamate ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-hydroxymethyl-2-phenyl-1,3-dioxolane (33868-51-8) + di(succinimido) carbonate (74124-79-1) + methylamine hydrochloride (593-51-1) → N-methyl-O-phenacylcarbamate ethylene acetal (1314096-76-8)

Guidance literature:

2-hydroxymethyl-2-phenyl-1,3-dioxolane; di(succinimido) carbonate; With dmap; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;

methylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; for 1h;

DOI:10.1039/c1ob05253e

Reference yield:

2-hydroxymethyl-2-phenyl-1,3-dioxolane (33868-51-8) + methylamine (74-89-5) → N-methyl-O-phenacylcarbamate ethylene acetal (1314096-76-8)

Guidance literature:

2-hydroxymethyl-2-phenyl-1,3-dioxolane; With dmap; di(succinimido) carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

methylamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2016.12.081

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-methyl-O-phenacylcarbamate ethylene acetal (1314096-76-8) → C13H17NO5 (1314096-77-9)

Guidance literature:

With sodium carbonate; In 1,2-dimethoxyethane; water; at 20 ℃; for 2h;

DOI:10.1039/c1ob05253e

upstream raw materials:

2-hydroxymethyl-2-phenyl-1,3-dioxolane

di(succinimido) carbonate

methylamine hydrochloride

methylamine

Downstream raw materials:

C₁₃H₁₇NO₅

Nα-Fmoc-S-(N-methyl-phenacyloxycarbamidomethyl)cysteine

Refernces

• 1、 Katayama, Hidekazu,Nakahara, Yoshiaki,Hojo, Hironobu. "N-Methyl-phenacyloxycarbamidomethyl (Pocam) group: A novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions". experimental part. p. 4653 - 4661. Retrieved 2011/07/31.