1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride

Base Information

• Chemical Name: 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride
• CAS No.: 78204-84-9
• Molecular Formula: C₉H₁₆N₂*ClH
• Molecular Weight: 188.7
• Mol file: 78204-84-9.mol

Synonyms:1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride

Chemical Property of 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride

There total 9 articles about 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2,83329-50-4) + dichlorodiphenylgermane (1613-66-7) → (C6H5)2ClGeNHC6H5O2S (135389-29-6) + 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride (78204-84-9)

Guidance literature:

In benzene; inert atmosphere; addn. of DBU soln. to soln. of Ph2GeCl2 and thiophene derivative, then 36 h, 20°C; filtration off of DBU.HCl, evapn. (reduced pressure), distn. (vac.); elem. anal.;

DOI:10.1016/0022-328X(91)86138-G

Reference yield: 98.0%

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) + dichlorodimesitylgermane (96481-42-4) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2,83329-50-4) → ((CH3)3C6H2)2ClGeNHC6H5O2S (144975-54-2,135389-30-9) + 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride (78204-84-9)

Guidance literature:

In benzene; inert atmosphere; addn. of DBU soln. to soln. of Mes2GeCl2 and thiophene derivative, then 24 h, 20°C; filtration off of DBU.HCl, evapn. (reduced pressure);

DOI:10.1016/0022-328X(91)86138-G

Reference yield: 78.0%

(triphenylphosphine)gold(I) chloride (14243-64-2) + Re(CO)4(H)(P(C6H5)2)Mo(C5H5)(CO)2 (134594-79-9) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2,83329-50-4) → Re(CO)4(P(C6H5)2)(AuP(C6H5)3)Mo(C5H5)(CO)2 (134594-80-2) + 1,8-diazabicyclo<5.4.0>undec-7-ene hidrochloride (78204-84-9)

Guidance literature:

In tetrahydrofuran; (Ar), reacted for 4 h with DBU, Au-compound added; filtered after 30 min, reduced to dryness, HPLC (CH2Cl2/n-hexane, 23.3 min), elem. anal.;

upstream raw materials:

Re(N-2,6-C₆H₃Cl₂)2(CH₂t-Bu)Cl₂

1,8-diazabicyclo[5.4.0]undec-7-ene

Re(N-2,6-C₆H₃Me₂)2(CH₂t-Bu)Cl₂

Re(N-2,6-C₆H₃i-Pr₂)2(CH₂t-Bu)Cl₂

Downstream raw materials:

C₉H₁₆N₂*H⁽¹⁺⁾*PtBr₅(P(C₆H₅)3)^(1-) = C₉H₁₇N₂{PtBr₅(P(C₆H₅)3)}

1,8-diazabicyclo[5.4.0]undec-7-ene

Refernces

• 1、 Carafa, Marianna,Mesto, Ernesto,Quaranta, Eugenio. "DBU-promoted nucleophilic activation of carbonic acid diesters". experimental part. p. 2458 - 2465. Retrieved 2011/06/10.