Acetylcholine chloride

Base Information

• Chemical Name: Acetylcholine chloride
• CAS No.: 60-31-1
• Deprecated CAS: 1784-29-8,70623-44-8,2028303-10-6,70623-44-8
• Molecular Formula: C7H16NO2^.Cl
• Molecular Weight: 181.663
• Hs Code.: 29379000
• European Community (EC) Number: 200-468-8
• NSC Number: 755845
• UNII: AF73293C2R
• DSSTox Substance ID: DTXSID5048978
• Wikidata: Q27105659
• NCI Thesaurus Code: C47382
• RXCUI: 20814
• Pharos Ligand ID: RN9JTC51H81M
• Metabolomics Workbench ID: 52914
• ChEMBL ID: CHEMBL1184
• Mol file: 60-31-1.mol

Synonyms:2-(Acetyloxy)-N,N,N-trimethylethanaminium;Acetilcolina Cusi;Acetylcholine;Acetylcholine Bromide;Acetylcholine Chloride;Acetylcholine Fluoride;Acetylcholine Hydroxide;Acetylcholine Iodide;Acetylcholine L Tartrate;Acetylcholine L-Tartrate;Acetylcholine Perchlorate;Acetylcholine Picrate;Acetylcholine Picrate (1:1);Acetylcholine Sulfate (1:1);Bromide, Acetylcholine;Bromoacetylcholine;Chloroacetylcholine;Cusi, Acetilcolina;Fluoride, Acetylcholine;Hydroxide, Acetylcholine;Iodide, Acetylcholine;L-Tartrate, Acetylcholine;Miochol;Perchlorate, Acetylcholine

Chemical Property of Acetylcholine chloride

Chemical Property:

• Appearance/Colour: White crystalline powder
• Melting Point: 146-150 °C(lit.)
• Refractive Index: 1.5560 (estimate)
• PSA: 26.30000
• Density: 1.1235 (rough estimate)
• LogP: -2.74030
• Storage Temp.: 0-6°C
• Sensitive.: Hygroscopic
• Solubility.: H2O: 0.1 g/mL, clear, colorless
• Water Solubility.: Soluble IN COLD WATER
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 181.0869564
• Heavy Atom Count: 11
• Complexity: 115

Purity/Quality:

99.5% ^*data from raw suppliers

Acetylcholine chloride 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)OCC[N+](C)(C)C.[Cl-]
• Recent EU Clinical Trials: PROgnostic value of precision medicine in patients with Myocardial Infarction and non-obStructive coronary artEries: the PROMISE study.
• Recent NIPH Clinical Trials: Study of sweating function with QSART in collagen diseases
• Description: Acetylcholine is a neurotransmitter that binds to nicotinic and muscarinic acetylcholine receptors (AChRs) in the central and peripheral nervous systems. It mediates motor function at the neuromuscular junction but also has functions in the parasympathetic and sympathetic nervous systems. It is involved in learning and memory through actions at nicotinic AChRs in the CNS. The actions of acetylcholine are terminated primarily via the action of acetylcholinesterase, which breaks it down into acetate and choline. Acetylcholine (chloride) mimics the effects of acetylcholine and has been used to determine the function of acetylcholine in various biological processes. Acetylcholine (chloride) inhibits peptide aggregation of p53 mutants in vitro at micromolar concentrations. It increases alveolar fluid clearance in a dose-dependent manner and enhances Na+/K+-ATPase activity, effects which are blocked by atropine , in a mouse model of pulmonary edema.
• Uses: Acetylcholine Chloride is a cholinergic. cholinergic, antiarrhythmic, miotic, vasodilator (peripheral) endogenous neurotransmitter at cholinergic synapses; amplifies sarcolemma action potential inducing muscle contractions A cholinergic neurotransmitter that can induce the opening of calcium channels
• Clinical Use: Atropine blocks the depressant effect of ACh on cardiacmuscle and its production of peripheral vasodilation (i.e.,muscarinic effects) but does not affect the skeletal musclecontraction (i.e., nicotinic effect) produced.ACh chloride is a hygroscopic powder that is available inan admixture with mannitol to be dissolved in sterile waterfor injection shortly before use. It is a short-acting mioticwhen introduced into the anterior chamber of the eye and isespecially useful after cataract surgery during the placementof sutures. When applied topically to the eye, it has littletherapeutic value because of poor corneal penetration andrapid hydrolysis by AChE.

Technology Process of Acetylcholine chloride

There total 14 articles about Acetylcholine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

choline chloride (67-48-1) + acetic anhydride (108-24-7) → acetylcholine chloride (60-31-1,70623-44-8)

Guidance literature:

Reference yield:

choline chloride (67-48-1) + acetyl chloride (75-36-5) → acetylcholine chloride (60-31-1,70623-44-8)

Guidance literature:

Reference yield:

trimethylamine (75-50-3) → acetylcholine chloride (60-31-1,70623-44-8)

Guidance literature:

With benzene;

upstream raw materials:

choline chloride

acetic anhydride

acetyl chloride

trimethylamine

Downstream raw materials:

choline chloride

4-(4-aminophenylazo)naphthalen-1-amine

Refernces

• 1、 Sinha, Anshu Kumar,Vigalok, Arkadi,Rawat, Varun. "Catalytic application of zinc complex of oxygen depleted 1,3-bis(pyrazole)-p-tert-butylcalix[4]arene". supporting information. p. 796 - 799. Retrieved 2019/02/14.
• 2、 Zelder, Felix H.,Rebek Jr., Julius. "Cavitand templated catalysis of acetylcholine". . p. 753 - 754. Retrieved 2008/02/03.