2-(4-(Dimethylamino)phenyl)ethanol

Base Information

• Chemical Name: 2-(4-(Dimethylamino)phenyl)ethanol
• CAS No.: 50438-75-0
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• Hs Code.: 2922199090
• European Community (EC) Number: 626-817-8
• UNII: 84GFY3663N
• DSSTox Substance ID: DTXSID6049309
• Nikkaji Number: J149.982C
• Wikidata: Q27269524
• ChEMBL ID: CHEMBL3560098
• Mol file: 50438-75-0.mol

Synonyms:2-(4-(Dimethylamino)phenyl)ethanol;50438-75-0;4-(Dimethylamino)phenethyl alcohol;2-[4-(Dimethylamino)phenyl]ethanol;4-(Dimethylamino)benzeneethanol;Benzeneethanol, 4-(dimethylamino)-;n,n-dimethyl-p-aminophenethanol;p-N,N-Dimethylaminophenethanol;DTXSID6049309;84GFY3663N;2-[4-(dimethylamino)phenyl]ethan-1-ol;CCRIS 987;2-(4-Dimetylaminophenyl)ethanol;2-(4-dimethylaminophenyl)ethanol;UNII-84GFY3663N;SCHEMBL66152;4-dimethylaminophenethyl alcohol;2(4-dimethylaminophenyl)ethanol;CHEMBL3560098;DTXCID5029265;CDTPAAZQBPSVGS-UHFFFAOYSA-;2-(4-dimethylamino-phenyl)ethanol;Tox21_202921;2-(4-(dimethylamino)phenyl) ethanol;AKOS009157979;2-[4-(Dimethylamino)phenyl]ethanol #;DS-2094;FS-3576;p-(N,N-dimethylamino)phenethyl Alcohol;SB76575;2-(P-DIMETHYLAMINOPHENYL)ETHANOL;NCGC00260467-01;2-(4-(DIMETHYLAMINOPHENYL)ETHANOL;PHENETHYL ALCOHOL, P-DIMETHYLAMINO-;2-[4-(Dimethylamino)phenyl]ethanol, 98%;CAS-50438-75-0;CS-0151320;FT-0608636;2-[4-(Dimethylamino)phenyl]ethanol, >=99%;EN300-1238583;1-(n,n-dimethylamino)-4-(2-hydroxyethyl)benzene;A871560;Q27269524;InChI=1/C10H15NO/c1-11(2)10-5-3-9(4-6-10)7-8-12/h3-6,12H,7-8H2,1-2H3

Chemical Property of 2-(4-(Dimethylamino)phenyl)ethanol

Chemical Property:

• Vapor Pressure: 0.00139mmHg at 25°C
• Melting Point: 54-58oC(lit.)
• Boiling Point: 284.5°Cat760mmHg
• PKA: 15.07±0.10(Predicted)
• Flash Point: 136.5°C
• PSA: 23.47000
• Density: 1.047g/cm³
• LogP: 1.28740
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 117

Purity/Quality:

99%, ^*data from raw suppliers

2-[4-(Dimethylamino)phenyl]ethanol ≥99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)CCO
• Uses: 2-[4-(Dimethylamino)phenyl]ethanol (4-(Dimethylamino)phenethyl alcohol) may be used as accelerator to investigate the the curing of bone cement at molecular level by electron spin resonance (ESR) spectroscopy. 2-[4-(Dimethylamino)phenyl]ethanol (4-(N,N-dimethylamino)phenethyl alcohol) may be used to compare the efficiency of different camphorquinone (CQ)/amine photo-initiating systems for the photopolymerization of a model dental resin.

Technology Process of 2-(4-(Dimethylamino)phenyl)ethanol

There total 7 articles about 2-(4-(Dimethylamino)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,2,2-trichloro-1-[4-(dimethylamino)phenyl]ethan-1-ol (66379-84-8) → 2-(4-dimethylaminophenyl)ethyl alcohol (50438-75-0)

Guidance literature:

With lithium borohydride; sodium hydroxide; In isopropyl alcohol; Temperature; Heating; Inert atmosphere;

DOI:10.1002/ejoc.201501089

Reference yield: 90.0%

2-[4-(dimethylamino)phenyl]acetic acid (17078-28-3) → 2-(4-dimethylaminophenyl)ethyl alcohol (50438-75-0)

Guidance literature:

With borane; In tetrahydrofuran; at 0 ℃; for 5h;

DOI:10.1021/jm030181q

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-nitrophenyl)ethanol (100-27-6) → 2-(4-dimethylaminophenyl)ethyl alcohol (50438-75-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 2844.3 Torr;

DOI:10.1021/ja00844a030

upstream raw materials:

formaldehyd

2-(4-nitrophenyl)ethanol

N,N-dimethy-4-vinylaniline

2-[4-(dimethylamino)phenyl]acetic acid

Downstream raw materials:

2-(4-dimethylaminophenyl)ethyl methyl 4-(4-cyano-2-pyridyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

4-dimethylaminobenzeneacetic acid methyl ester

4-((1H-benzimidazol-2-yl)methyl)-N,N-dimethylaniline

p-(N,N-dimethylamino)phenethyl bromide

Refernces

• 1、 Lloyd, Matthew G.,D'Acunto, Mariantonietta,Taylor, Richard J.K.,Unsworth, William P.. "α-Alkylidene-γ-butyrolactone synthesis via one-pot C-H insertion/olefination: substrate scope and the total synthesis of (±)-cedarmycins A and B". . p. 7107 - 7123. Retrieved 2015/02/19.
• 2、 Avery, Mitchell A.,Muraleedharan, Kannoth M.,Desai, Prashant V.,Bandyopadhyaya, Achintya K.,Furtado, Marise M.,Tekwani, Babu L.. "Structure-activity relationships of the antimalarial agent artemisinin. 8. Design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria". . p. 4244 - 4258. Retrieved 2007/10/03.