Technology Process of Homomoschatoline
There total 9 articles about Homomoschatoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2-aminophenyl)(5,6,7-trimethoxyisoquinolin-1-yl)methanone;
With
sulfuric acid; sodium nitrite;
In
water;
at 0 - 8 ℃;
for 0.25h;
With
copper;
In
water;
at 60 ℃;
DOI:10.1039/c8ra05338c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate / acetonitrile / 2 h / Reflux
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(ll) bromide; oxygen / dimethyl sulfoxide / 8 h / 35 °C / Green chemistry
3.1: iron; acetic acid / water; ethanol / 70 °C / Inert atmosphere
4.1: sulfuric acid; sodium nitrite / water / 0.25 h / 0 - 8 °C
4.2: 60 °C
With
sulfuric acid; oxygen; iron; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(ll) bromide; sodium nitrite; trichlorophosphate;
In
ethanol; water; dimethyl sulfoxide; acetonitrile;
1.1: |Bischler-Napieralski Reaction;
DOI:10.1039/c8ra05338c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: iron; acetic acid / water; ethanol / 70 °C / Inert atmosphere
2.1: sulfuric acid; sodium nitrite / water / 0.25 h / 0 - 8 °C
2.2: 60 °C
With
sulfuric acid; iron; acetic acid; sodium nitrite;
In
ethanol; water;
DOI:10.1039/c8ra05338c