4-Methoxy-2,6-xylenol

Base Information

• Chemical Name: 4-Methoxy-2,6-xylenol
• CAS No.: 2431-91-6
• Molecular Formula: C9H12 O2
• Molecular Weight: 152.193
• Hs Code.: 2909500000
• Mol file: 2431-91-6.mol

Synonyms:2,6-Xylenol,4-methoxy- (7CI,8CI); 2,6-Dimethyl-4-methoxyphenol;4-Methoxy-2,6-dimethylphenol; 4-Methoxy-2,6-xylenol; NSC 128407

Chemical Property of 4-Methoxy-2,6-xylenol

Chemical Property:

• Melting Point: 77 °C
• Boiling Point: 263.6°Cat760mmHg
• PKA: 11.16±0.23(Predicted)
• Flash Point: 130°C
• PSA: 29.46000
• Density: 1.053g/cm³
• LogP: 2.01760

Purity/Quality:

99%min ^*data from raw suppliers

4-Methoxy-2,6-dimethylphenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-2,6-xylenol

There total 21 articles about 4-Methoxy-2,6-xylenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + 1,4-dihydroxy-2,6-dimethylbenzene (654-42-2) → 4-methoxy-2,6-dimethylphenol (2431-91-6)

Guidance literature:

With sulfuric acid; Heating;

Reference yield: 85.0%

bis(2,6-dimethyl-4-methoxyphenyl)hydroxyborane (50481-12-4) → 4-methoxy-2,6-dimethylphenol (2431-91-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; Ambient temperature;

DOI:10.1016/S0040-4020(01)85690-8

Reference yield: 64.0%

1,4-dihydroxy-2,6-dimethylbenzene (654-42-2) → 4-methoxy-2,6-dimethylphenol (2431-91-6)

Guidance literature:

With sulfuric acid; In methanol; at 100 ℃; for 4h;

DOI:10.1002/anie.201310491

upstream raw materials:

methanol

1,4-dihydroxy-2,6-dimethylbenzene

2.6-dimethylphenol

4-methoxy-2,6-dimethylaniline

Downstream raw materials:

(Me)2(OMe)(C₆H₄OMe)cyclohexa-2,4-dienone

4-methoxy-2,6-dimethyl-6-<(E)-styryl>cyclohexa-2,4-dienone

2,6-dimethyl 4-methoxy 6-phenyl 2,4-cyclohexadienone

3-bromo-4-methoxy-2,6-dimethylphenol

Refernces

• 1、 Pelter, Andrew,Drake, Robert. "Hindered organoboron groups in organic chemistry. 28 The solvolyses of bis(2,6-dimethyl-4-methoxyphenyl)organylboranes, (DMP)2BR". . p. 13801 - 13828. Retrieved 1994.
• 2、 Zhao, Wenjun,Huang, Li,Guan, Yong,Wulff, William D.. "Three-component asymmetric catalytic ugi reaction - Concinnity from diversity by substrate-mediated catalyst assembly". supporting information. p. 3436 - 3441. Retrieved 2014/04/03.
• 3、 -. "SYNTHESIS OF DISCODERMOLIDE". Page 89; 90. . Retrieved 2010/11/30.