4-(Hydroxymethyl)phenoxyacetic acid

Base Information

• Chemical Name: 4-(Hydroxymethyl)phenoxyacetic acid
• CAS No.: 68858-21-9
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 29189900
• Mol file: 68858-21-9.mol

Synonyms:Acetic acid,[4-(hydroxymethyl)phenoxy]- (9CI);2-[4-(Hydroxymethyl)phenoxy]acetic acid;HMP Linker;

Chemical Property of 4-(Hydroxymethyl)phenoxyacetic acid

Chemical Property:

• Appearance/Colour: White to off-white powder
• Vapor Pressure: 2.13E-06mmHg at 25°C
• Melting Point: 112-114 °C
• Boiling Point: 378.3 °C at 760 mmHg
• PKA: 3.15±0.10(Predicted)
• Flash Point: 156.3 °C
• PSA: 66.76000
• Density: 1.316 g/cm³
• LogP: 0.64230
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(Hydroxymethyl)phenoxyacetic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36/37/39-27-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-(Hydroxymethyl)phenoxyacetic acid is a linkage agent used in solid-phase peptide synthesis according to the "FMOC-polyamide" technique.

Technology Process of 4-(Hydroxymethyl)phenoxyacetic acid

There total 6 articles about 4-(Hydroxymethyl)phenoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(4-formylphenoxy)acetic acid (22042-71-3) → [4-(hydroxymethyl)phenoxy]acetic acid (68858-21-9)

Guidance literature:

With sodium tetrahydroborate; potassium hydroxide; sodium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1515/mgmc-2015-0025

Reference yield: 53.0%

4-chloromethylphenoxyacetic acid (77284-29-8) → [4-(hydroxymethyl)phenoxy]acetic acid (68858-21-9)

Guidance literature:

With sodium hydrogencarbonate; In water;

DOI:10.1039/P19810000538

Reference yield:

sodium hydrogencarbonate (144-55-8) + 4-bromomethylphenoxyacetic acid (126771-41-3) → [4-(hydroxymethyl)phenoxy]acetic acid (68858-21-9)

Guidance literature:

upstream raw materials:

4-chloromethylphenoxyacetic acid

2-phenoxyacetic acid

sodium hydrogencarbonate

4-bromomethylphenoxyacetic acid

Downstream raw materials:

phenylcarbonylmethyl <4-(hydroxymethyl)phenoxy>acetate

KNI-10125

Refernces

• 1、 Zhang, Hao,Yu, Haixia,Liu, Xijie,Tian, Laijin. "Synthesis, structural characterization, and antibacterial activity of tricyclohexyltin aryloxyacetates". . p. 157 - 164. Retrieved 2015/12/09.
• 2、 -. "Racemization free attachment of amino acids to a solid phase". . . Retrieved 2008/06/13.