ALLOPREGNANOLONE ACETATE

Base Information

• Chemical Name: ALLOPREGNANOLONE ACETATE
• CAS No.: 906-83-2
• Molecular Formula: C23H36 O3
• Molecular Weight: 360.537
• Mol file: 906-83-2.mol

Synonyms:5a-Pregnan-20-one, 3b-hydroxy-, acetate (6CI,7CI,8CI);20-Oxo-5a-pregnan-3b-yl acetate; 3b-Acetoxy-20-oxo-5a-pregnane; 3b-Acetoxy-5a-pregnan-20-one; 3b-Hydroxy-5a-pregnan-20-one acetate;5,6-Dihydropregnenolone acetate; Allopregnan-3b-ol-20-one acetate; NSC 18318

Chemical Property of ALLOPREGNANOLONE ACETATE

Chemical Property:

• Vapor Pressure: 4.55E-08mmHg at 25°C
• Boiling Point: 443.7°Cat760mmHg
• Flash Point: 189.4°C
• PSA: 43.37000
• Density: 1.07g/cm³
• LogP: 5.16600

Purity/Quality:

98%,99%, ^*data from raw suppliers

5α-Pregnan-3β-ol-20-one 3β-acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5α-Pregnan-3β-ol-20-one 3β-Acetate is a derivative of Pregnenolone (P712200); a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A.

Technology Process of ALLOPREGNANOLONE ACETATE

There total 22 articles about ALLOPREGNANOLONE ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Pregnenolone acetate (1778-02-5) → isopregnanolone (516-55-2) + pregnenolone acetate (906-83-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 20 ℃; under 10343.2 Torr;

DOI:10.1016/j.ejmech.2013.11.019

Reference yield: 99.0%

3β-hydroxy-(5ξ)-pregnan-20-one (128-20-1,128-21-2,516-54-1,516-55-2,4243-94-1,4320-08-5,4406-35-3,4406-37-5,4469-03-8,13089-85-5,13089-86-6,14615-01-1,21788-58-9,24557-99-1,25126-79-8,26961-00-2,36027-63-1,39845-99-3,40135-22-6,72691-57-7,81076-02-0,95118-68-6,110350-90-8) + acetic anhydride (108-24-7) → Pregnanolon-3β-acetat (906-83-2,1491-77-6,2394-44-7,6003-24-3,10002-82-1,23097-04-3,33999-95-0,34000-02-7,40129-07-5,65556-92-5,95720-67-5,95720-68-6,95720-69-7,96611-81-3,102679-41-4,106760-08-1)

Guidance literature:

With pyridine; In pyridine; at 20 ℃; for 2h;

Reference yield: 60.0%

17α,21-dichloro-3β-acetoxy-5α-pregnan-20-one (209979-66-8) → pregnenolone acetate (906-83-2) + 3β-acetoxy-5α-pregn-16-en-20-one (1169-20-6)

Guidance literature:

With sodium acetate; acetic acid; sodium iodide; Heating;

upstream raw materials:

Pregnenolone acetate

acetic acid

acetic acid-(20-hydroxy-24.24-dimethyl-cholanyl-⁽³⁾-ester)

17α,21-dichloro-3β-acetoxy-5α-pregnan-20-one

Downstream raw materials:

5-androgen-3,17-diol

androstanedione

3β-hydroxy-5α-etianic acid

isopregnanolone

Refernces

• 1、 -. "HELIX 12 DIRECTED STEROIDAL PHARMACEUTICAL PRODUCTS". Page/Page column 139. . Retrieved 2010/02/12.
• 2、 Yoshii,Koizumi,Hayashi,Hiroi. "Selective reduction of conjugated enones and dienones with trialkylsilane and titanium tetrachloride". . p. 1468 - 1470. Retrieved 2007/10/13.