Technology Process of 1-(4-bromophenyl)-4-methylbicyclo[2.2.2]octane
There total 7 articles about 1-(4-bromophenyl)-4-methylbicyclo[2.2.2]octane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; aluminium trichloride;
In
nitrobenzene;
1.) 80 deg C; 2.) 20 min;
DOI:10.1039/P29810000026
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 74 percent / sodium hydroxide, water / 10 h / Heating
2: 63 percent / acetic anhydride / 14 h / Heating
3: 71 percent / potassium hydroxide, water / 6 h / 70 °C / Heating
4: 87 percent / 1.) hydrazine hydrate;2.) potassium hydroxide, diethylene glycol / 1.) reflux, 5 h; 2.) 230 deg C - 240 deg C, 20 h
5: 69 percent / zinc bromide, 50percent hydrobromic acid / 16 h / 60 - 70 °C / Heating
6: 53 percent / 1.) anhydrous aluminium chloride; 2.) 15percent hydrochloric acid / nitrobenzene / 1.) 80 deg C; 2.) 20 min
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; aluminium trichloride; water; hydrogen bromide; acetic anhydride; hydrazine hydrate; zinc dibromide; diethylene glycol;
In
nitrobenzene;
DOI:10.1039/P29810000026
