2-[2-(BENZYLOXY)ETHOXY]ETHANOL

Base Information

• Chemical Name: 2-[2-(BENZYLOXY)ETHOXY]ETHANOL
• CAS No.: 2050-25-1
• Molecular Formula: C11H16O3
• Molecular Weight: 196.246
• Hs Code.: 29094990
• Mol file: 2050-25-1.mol

Synonyms:Ethanol,2-[2-(benzyloxy)ethoxy]- (7CI,8CI);2-[2-(Benzyloxy)ethoxy]ethanol;Benzyl DiGlycol;BzDG;Diethylene glycol monobenzyl ether;NSC 23567;

Chemical Property of 2-[2-(BENZYLOXY)ETHOXY]ETHANOL

Chemical Property:

• Vapor Pressure: 0.000245mmHg at 25°C
• Refractive Index: n20/D 1.51(lit.)
• Boiling Point: 311.2 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 142 °C
• PSA: 38.69000
• Density: 1.078 g/cm³
• LogP: 1.21210
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diethylene Glycol Monobenzyl Ether ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Benzyl-PEG3-alcohol is a PEG linker with an acid labile, benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
• Uses: Di(ethylene glycol) benzyl ether may be used as an initiator in the preparation of linear-PLA (poly(L-lactide).

Technology Process of 2-[2-(BENZYLOXY)ETHOXY]ETHANOL

There total 12 articles about 2-[2-(BENZYLOXY)ETHOXY]ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

benzyl bromide (100-39-0) + diethylene glycol (111-46-6) → diethylene glycol monobenzyl ether (2050-25-1,1201808-31-2)

Guidance literature:

diethylene glycol; With sodium hydride; In tetrahydrofuran; at 0 ℃;

benzyl bromide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/b915548a

Reference yield: 76.0%

oxirane (75-21-8,99932-75-9) + benzyl alcohol (100-51-6,185532-71-2) → diethylene glycol monobenzyl ether (2050-25-1,1201808-31-2)

Guidance literature:

at 95 ℃; for 2h;

Reference yield: 74.0%

benzyl chloride (100-44-7) + diethylene glycol (111-46-6) → diethylene glycol monobenzyl ether (2050-25-1,1201808-31-2)

Guidance literature:

With sodium hydroxide; at 100 ℃; for 24h;

upstream raw materials:

oxirane

benzyl alcohol

benzyl chloride

diethylene glycol

Downstream raw materials:

Benzylether von Monopentoxymethylether des Diethylenglykols

2-Hexyloxymethoxy-2'-benzyloxy-diethylether

benzyl (2-(2-chloroethoxy)ethyl) ether

2-Diethylaminomethoxy-2'-benzyloxy-diethylether

Refernces

• 1、 Jia, Yimin,Qin, Hongmei,Wang, Na,Jiang, Zhong-Xing,Yang, Zhigang. "Fe2O3-Promoted Intermolecular Chlorotrifluoromethylthiolation of Alkenes". . p. 2808 - 2817. Retrieved 2018/03/09.
• 2、 -. "Phosphamide derivative substituted by aryl group and medical applications thereof including a use in manufacturing drugs for treating virus infectious diseases". Page/Page column 24; 25. . Retrieved 2017/10/14.