Technology Process of C34H50N2OSi
There total 7 articles about C34H50N2OSi which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile;
With
diisobutylaluminium hydride;
In
diethyl ether; hexane;
at -78 ℃;
for 3h;
isobutylamine;
With
ammonium bromide;
In
methanol; diethyl ether; hexane;
at 20 ℃;
for 3h;
With
sodium tetrahydroborate;
In
methanol; diethyl ether; hexane;
at 20 ℃;
Cooling with ice;
DOI:10.1002/cmdc.201200271
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide; potassium carbonate / water / 3 h / Reflux
2.1: lithium aluminium tetrahydride / diethyl ether / 0 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 0 °C
3.2: 1 h
4.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / -20 °C
5.1: 1H-imidazole / dichloromethane / 0 - 20 °C
6.1: diisobutylaluminium hydride / diethyl ether; hexane / 3 h / -78 °C
6.2: 3 h / 20 °C
6.3: 20 °C / Cooling with ice
With
1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; sodium hydroxide;
In
diethyl ether; hexane; dichloromethane; water;
3.1: |Swern Oxidation;
DOI:10.1002/cmdc.201200271
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / -20 °C
2.1: 1H-imidazole / dichloromethane / 0 - 20 °C
3.1: diisobutylaluminium hydride / diethyl ether; hexane / 3 h / -78 °C
3.2: 3 h / 20 °C
3.3: 20 °C / Cooling with ice
With
1H-imidazole; boron trifluoride diethyl etherate; diisobutylaluminium hydride;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1002/cmdc.201200271
