Technology Process of 1-cyclopropyl-3-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea
There total 14 articles about 1-cyclopropyl-3-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sulfuric acid / 18 h / 34 - 50 °C
2: sodium hexamethyldisilazane / tetrahydrofuran / 5.03 h / -70 - -40 °C
3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 760.05 Torr / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / -10 - 20 °C
5: methanol / bis(acetylacetonate)oxovanadium / tetrahydrofuran / 18 h / 20 - 35 °C / 760.05 Torr
6: potassium carbonate / dimethyl sulfoxide / 2.5 h / 20 - 35 °C
7: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 1.95 h / 100 - 110 °C
With
methanol; sulfuric acid; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; bis(acetylacetonate)oxovanadium; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide;
- Guidance literature:
-
With
sodium hydrogencarbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;
at 100 - 110 ℃;
for 1.95h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C
2: sodium t-butanolate / dimethyl sulfoxide / 16.2 h / 20 °C / Cooling with ice
3: sodium t-butanolate / dimethyl sulfoxide / 16 h / 0 - 20 °C
4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 1.95 h / 100 - 110 °C
With
sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; dimethyl sulfoxide;