6-AMINOCOUMARIN HYDROCHLORIDE

Base Information

• Chemical Name: 6-AMINOCOUMARIN HYDROCHLORIDE
• CAS No.: 63989-79-7
• Molecular Formula: C9H7 N O2 . Cl H
• Molecular Weight: 197.63
• Mol file: 63989-79-7.mol

Synonyms:2H-1-Benzopyran-2-one,6-amino-, hydrochloride (9CI); 6-Amino-1,2-benzopyrone hydrochloride; 6-Aminocoumarinhydrochloride; NSC 613801

Chemical Property of 6-AMINOCOUMARIN HYDROCHLORIDE

Chemical Property:

• Melting Point: >260oC (dec.)
• Boiling Point: 396.9°Cat760mmHg
• Flash Point: 231°C
• PSA: 56.23000
• Density: g/cm³
• LogP: 2.75840
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

6-AminocoumarinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-20/21/22-36
• Safety Statements: 22-36/37-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Aminocoumarin hydrochloride is used as a pharmaceutical intermediate.

Technology Process of 6-AMINOCOUMARIN HYDROCHLORIDE

There total 4 articles about 6-AMINOCOUMARIN HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 6-Aminocoumarin Hydrochloride (63989-79-7)

Guidance literature:

Reference yield: 53.0%

6-nitrocoumarin (2725-81-7) → 6-Aminocoumarin Hydrochloride (63989-79-7)

Guidance literature:

6-nitrocoumarin; With hydrogen; nickel; In methanol; at 20 ℃;

With hydrogenchloride; In ethanol;

DOI:10.1016/j.bmc.2004.07.014

Reference yield:

6-aminocoumarin (14415-44-2) → 6-Aminocoumarin Hydrochloride (63989-79-7)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1016/j.poly.2010.12.037

upstream raw materials:

6-nitrocoumarin

6-aminocoumarin

coumarin

Downstream raw materials:

6-nitroso-1,2-benzopyrone

(+/-)-6-([(6-bromo-2-methoxy-quinolin-3-yl)-phenylmethyl]-amino)-chromen-2-one

Refernces

• 1、 Heinrich, Timo,B?ttcher, Henning,Schiemann, Kai,H?lzemann, Günter,Schwarz, Michael,Bartoszyk, Gerd D.,Van Amsterdam, Christoph,Greiner, Hartmut E.,Seyfried, Christoph A.. "Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity". . p. 4843 - 4852. Retrieved 2007/10/03.