2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester

Base Information

• Chemical Name: 2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester
• CAS No.: 155388-65-1
• Molecular Formula: C₁₅H₂₁NO₅
• Molecular Weight: 295.335
• Mol file: 155388-65-1.mol

Synonyms:2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester

Chemical Property of 2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester

There total 1 articles about 2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,4,4-trimethylpentan-1-ol (16325-63-6) + 5-nitrosalicylic acid (96-97-9) → 2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester (155388-65-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; for 48h;

DOI:10.1021/jm00032a020

Reference yield: 97.0%

2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester (155388-65-1) → 5-Amino-2-hydroxy-benzoic acid 2,4,4-trimethyl-pentyl ester (155388-95-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h; under 760 Torr;

DOI:10.1021/jm00032a020

Reference yield:

2-Hydroxy-5-nitro-benzoic acid 2,4,4-trimethyl-pentyl ester (155388-65-1) → 2-hydroxy-5-{N-[(2,5-dihydroxyphenyl)methylidene]amino}benzoic acid 2,4,4,-trimethylpentyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr

2: 76 percent / Et₃N / methanol / 8 h / 60 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00032a020

upstream raw materials:

2,4,4-trimethylpentan-1-ol

5-nitrosalicylic acid

Downstream raw materials:

5-Amino-2-hydroxy-benzoic acid 2,4,4-trimethyl-pentyl ester

Refernces