N-(2-Hydroxyethyl)acetamide

Base Information

• Chemical Name: N-(2-Hydroxyethyl)acetamide
• CAS No.: 142-26-7
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• Hs Code.: 29241990
• European Community (EC) Number: 205-530-8
• NSC Number: 5999
• UNII: A9O0818TWD
• DSSTox Substance ID: DTXSID6044804
• Nikkaji Number: J2.542I
• Wikidata: Q27144824
• RXCUI: 1311639
• ChEMBL ID: CHEMBL3188272
• Mol file: 142-26-7.mol

Synonyms:N-(2-Hydroxyethyl)acetamide;N-Acetylethanolamine;142-26-7;2-Acetamidoethanol;Acetamide, N-(2-hydroxyethyl)-;Acetylcolamine;Acetamide MEA;2-Acetylaminoethanol;N-Ethanolacetamide;N-Acetyl-2-aminoethanol;Hydroxyethyl acetamide;N-Acetyl ethanolamine;ACETYLETHANOLAMINE;N-2-Hydroxyethylacetamide;Acetic monoethanolamide;beta-Hydroxyethylacetamide;NSC 5999;N-beta-Hydroxyethylacetamide;.beta.-Hydroxyethylacetamide;HSDB 2713;EINECS 205-530-8;BRN 1811708;UNII-A9O0818TWD;Acetic acid amide, N-(2-hydroxyethyl)-;AI3-02836;A9O0818TWD;DTXSID6044804;CHEBI:74687;N-(.beta.-Hydroxyethyl)acetamide;NSC-5999;4-04-00-01535 (Beilstein Handbook Reference);Hetamide MA;Carsamide AMEA;Lipamide MEAA;Amidex AME;Upamide ACMEA;N-acetyl-ethanolamine;Schercomid AME 70;Foamid AME-70;Foamid AME-75;Mackamide AME-100;Foamid AME-100;Incromectant AMEA-70;Incromectant AMEA-100;n-2-hydroxyethyl-acetamide;N- 2- hydroxyethylacetamide;WLN: Q2MV1;SCHEMBL48502;ACETAMIDE MEA [INCI];ACETAMIDE MEA [VANDF];N-(2-hydroxyethyl)-acetamide;acetamide, N-(2-hydroxyethyl);N-(2-hydroxy-ethyl)-acetamide;SCHEMBL9597207;CHEMBL3188272;DTXCID4024804;ACETYLETHANOLAMINE [HSDB];NSC5999;Acetamide, N -(2-hydroxyethyl)-;Tox21_301724;MFCD00002836;N-Acetylethanolamine, technical grade;STL283925;AKOS005206796;CS-W013689;FD10637;FS-4296;LS-9688;2,5-Dichloro-4-fluorophenacyl chloride;NCGC00256051-01;CAS-142-26-7;A0075;FT-0610934;EN300-15590;A885206;J-007626;Q27144824;2-Acetamidoethanol = Acetylethanolamine;2-(Acetamido)ethanol~N-(2-Hydroxyethyl)acetamide

Chemical Property of N-(2-Hydroxyethyl)acetamide

Chemical Property:

• Appearance/Colour: clear viscous white to yellow liquid
• Vapor Pressure: 0.00021mmHg at 25°C
• Melting Point: 15.8 °C
• Refractive Index: n20/D 1.472(lit.)
• Boiling Point: 291.471 °C at 760 mmHg
• PKA: 14.56±0.10(Predicted)
• Flash Point: 151.037 °C
• PSA: 49.33000
• Density: 1.052 g/cm³
• LogP: -0.49430
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water, 1e+006 mg/L @ 25°C (est), soluble in alcohol and ether.
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 103.063328530
• Heavy Atom Count: 7
• Complexity: 62.7

Purity/Quality:

99.9% ^*data from raw suppliers

N-Acetylethanolamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Ethanolamines
• Canonical SMILES: CC(=O)NCCO
• Uses: 2-Acetylaminoethanol is a humectant recommended for use in emulsions. It finds its uses as antistatic agent, foam boosting agent, hair conditioning humectant, skin conditioning surfactant and viscosity controlling agent in cosmetics industry. It is a non-tacky glycerine alternative for use in skin and hair care. It has humectant and lubricant properties for use in shampoos, treatment products and hair conditioners.

Technology Process of N-(2-Hydroxyethyl)acetamide

There total 40 articles about N-(2-Hydroxyethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Isopropyl acetate (108-21-4) + ethanolamine (141-43-5) → 2-acetylaminoethanol (142-26-7)

Guidance literature:

With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In acetonitrile; at 20 ℃; for 15h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol400987p

Reference yield: 99.0%

acetic anhydride (108-24-7) + ethanolamine (141-43-5) → 2-acetylaminoethanol (142-26-7)

Guidance literature:

With Cp₂Ti(OSO₂C₈F₁₇)2; at 20 ℃; for 0.0166667h; Neat (no solvent);

DOI:10.1016/j.jorganchem.2010.01.025

Reference yield: 99.0%

acetic acid methyl ester (79-20-9) + ethanolamine (141-43-5) → 2-acetylaminoethanol (142-26-7)

Guidance literature:

With N,N'-Mes₂imidazol-2-ylidene; In tetrahydrofuran; at 23 ℃; for 24h;

DOI:10.1021/ol050773y

upstream raw materials:

acetamide

sodium ethanolate

acetic anhydride

ethanolamine

Downstream raw materials:

β-(Acetylamino)ethyl-(4-nitro-1-phenyl)ether

methanol

3-acetyl-1,3-oxazolidin-2-one

chloroform

Refernces

• 1、 de Benneville et al.. "-". . p. 772. Retrieved 1956.
• 2、 Falk, Heinz,Sarhan, Abd-El-Wareth A. O.,Tran, Huyen T. N.,Altmann, Robert. "Synthesis and properties of hypericins substituted with acidic and basic residues: Hypericin tetrasulfonic acid - A water soluble hypericin derivative". . p. 309 - 318. Retrieved 1998.
• 3、 -. "Preparation method of N-vinyl alkylamide". Paragraph 0067-0068; 0073-0074. . Retrieved 2020/12/29.
• 4、 Yokoyama, Soichi,Shibauchi, Hiroshi,Asahara, Haruyasu,Nishiwaki, Nagatoshi. "Metal-Free O-Selective Direct Acylation of Amino Alcohols Through Pseudo-Intramolecular Process". . p. 1125 - 1133. Retrieved 2019/02/01.