2-METHYL-4(3H)-QUINAZOLINONE

Base Information

• Chemical Name: 2-METHYL-4(3H)-QUINAZOLINONE
• CAS No.: 1769-24-0
• Molecular Formula: C9H8 N2 O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• Mol file: 1769-24-0.mol

Synonyms:4(1H)-Quinazolinone,2-methyl- (7CI,9CI); 4-Quinazolinol, 2-methyl- (8CI);2-Methyl-3H-quinazolin-4-one; 2-Methyl-4(3H)-quinazolinone;2-Methyl-4(3H)-quinazolone; 2-Methyl-4-oxoquinazoline; 2-Methyl-4-quinazolinol;2-Methyl-4-quinazolinone; 2-Methyl-4-quinazolone; 2-Methylquinazolone;3H-2-Methyl-4-oxoquinazoline; 4-Hydroxy-2-methylquinazoline; NSC 12005; NSC2757

Chemical Property of 2-METHYL-4(3H)-QUINAZOLINONE

Chemical Property:

• Vapor Pressure: 0.000826mmHg at 25°C
• Melting Point: 231-233 °C(lit.)
• Refractive Index: 1.644
• Boiling Point: 305.4 °C at 760 mmHg
• PKA: 3.60±0.20(Predicted)
• Flash Point: 138.5 °C
• PSA: 45.75000
• Density: 1.26 g/cm³
• LogP: 1.23150
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-4(3H)-quinazolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Methyl-4(3H)-quinazolinone may be used in chemical synthesis.

Technology Process of 2-METHYL-4(3H)-QUINAZOLINONE

There total 166 articles about 2-METHYL-4(3H)-QUINAZOLINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

anthranilic acid amide (28144-70-9,88-68-6) + 1-phenylbutan-1,3-dione (93-91-4) → 2-methyl-4-quinazolone (1769-24-0)

Guidance literature:

With graphene oxide nanosheets; In water; at 60 ℃; for 6h;

DOI:10.1039/c6ra00388e

Reference yield: 97.0%

2-acetamidobenzonitrile (25116-00-1) → 2-methyl-4-quinazolone (1769-24-0)

Guidance literature:

With urea-hydrogen peroxide; potassium carbonate; In water; acetone; for 2h; Heating;

DOI:10.1080/00397919708006811

Reference yield: 93.0%

Triethyl orthoacetate (78-39-7) + anthranilic acid amide (28144-70-9,88-68-6) → 2-methyl-4-quinazolone (1769-24-0)

Guidance literature:

With antimony(III) chloride; In neat (no solvent); for 0.05h; Microwave irradiation; Green chemistry;

upstream raw materials:

2-methylquinazoline

ethyl N-acetylanthranilate

2-methyl-4H-benzo[1,3]oxazin-4-one

isatoic anhydride

Downstream raw materials:

2-(4'-Hydroxy-3'-nitrostyryl)-4(3H)-quinazolinone

3-benzyl-2-methyl-3H-quinazolin-4-one

[3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone

2-methyl-3-phenacylquinazolin-4-one

Refernces

• 1、 Abe, Takumi,Kida, Koshiro,Yamada, Koji. "A copper-catalyzed Ritter-type cascade via iminoketene for the synthesis of quinazolin-4(3H)-ones and diazocines". . p. 4362 - 4365. Retrieved 2017.
• 2、 Chen, Nan-Ying,Huang, Wan-Yun,Li, Xiao-Juan,Mo, Dong-Liang,Pan, Cheng-Xue,Su, Gui-Fa,Wei, Xin-Wei,Yuan, Jing-Mei. "2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents". . . Retrieved 2019.
• 3、 Ding, Pan-Pan,Gao, Man,Mao, Bei-Bei,Cao, Sheng-Li,Liu, Cui-Huan,Yang, Chao-Rui,Li, Zhong-Feng,Liao, Ji,Zhao, Hongchang,Li, Zheng,Li, Jing,Wang, Hailong,Xu, Xingzhi. "Synthesis and biological evaluation of quinazolin-4(3 H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents". . p. 364 - 373. Retrieved 2016.
• 4、 Mori, Miwako,Uozumi, Yasuhiro,Shibasaki, Masakatsu. "Incorporation of molecular nitrogen into organic compounds III. Reaction of titanium-nitrogen complexes with acid halides and acid anhydrides". . p. 255 - 267. Retrieved 1990.
• 5、 Hayun,Arrahman,Suryadi,Yanuar. "Microwave assisted synthesis of pyridin-1-ium salt of 6-nitroquinazolin-4-one and its 6-amino analog under ultrasonic irradiation". . p. 7904 - 7906. Retrieved 2014.
• 6、 Wang, Rongzhou,Liu, Shiyuan,Li, Longfei,Song, Ao,Yu, Shengsheng,Zhuo, Shuping,Xing, Ling-Bao. "Metal-free catalyst for the visible-light-induced photocatalytic synthesis of quinazolinones". . . Retrieved 2021/07/07.
• 7、 Xie, Zongbo,Lan, Jin,Zhu, Haibo,Lei, Gaoyi,Jiang, Guofang,Le, Zhanggao. "Visible light induced tandem reactions: An efficient one pot strategy for constructing quinazolinones using in-situ formed aldehydes under photocatalyst-free and room-temperature conditions". supporting information. p. 1427 - 1431. Retrieved 2020/11/02.