Kaempferol

Base Information

• Chemical Name: Kaempferol
• CAS No.: 520-18-3
• Molecular Formula: C15H10O6
• Molecular Weight: 286.241
• Hs Code.: 29329990
• Mol file: 520-18-3.mol

Synonyms:Flavone,3,4',5,7-tetrahydroxy- (7CI,8CI);3,4',5,7-Tetrahydroxyflavone;3'-Deoxyquercetin;5,7,4'-Trihydroxyflavonol;C.I. 75640;Indigo Yellow;Kaempferol;Kaempherol;Kampcetin;Kempferol;NSC 407289;NSC 656277;Nimbecetin;Pelargidenolon;Pelargidenon;Populnetin;Rhamnolutein;Rhamnolutin;Robigenin;Swartziol;Trifolitin;

Chemical Property of Kaempferol

Chemical Property:

• Appearance/Colour: Yellow solid
• Vapor Pressure: 6.38E-16mmHg at 25°C
• Melting Point: 276 °C
• Refractive Index: 1.767
• Boiling Point: 582.1 °C at 760 mmHg
• PKA: 6.34±0.40(Predicted)
• Flash Point: 226.1 °C
• PSA: 111.13000
• Density: 1.688 g/cm³
• LogP: 2.28240
• Storage Temp.: −20°C
• Solubility.: ethanol: 20 mg/mL

Purity/Quality:

98% ^*data from raw suppliers

Kaempferol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-68-25
• Safety Statements: 26-36-45-36/37-36/37/38-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: antidepressant, inhibits fatty acid amide hydrolase Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells. Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

Technology Process of Kaempferol

There total 192 articles about Kaempferol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

kaempferol-3-O-α-D-xylopyranosyl-(2a→1b)-2a-O-α-D-xylopyranosyl-(2b→1c)-2b-O-α-D-xylopyranosyl-(2c→1d)-2c-O-α-D-xylopyranosyl-2d-hexadecanoate (1449692-21-0) → D-xylose (58-86-6) + kaempferol (520-18-3) + 1-hexadecylcarboxylic acid (57-10-3)

Guidance literature:

kaempferol-3-O-α-D-xylopyranosyl-(2a→1b)-2a-O-α-D-xylopyranosyl-(2b→1c)-2b-O-α-D-xylopyranosyl-(2c→1d)-2c-O-α-D-xylopyranosyl-2d-hexadecanoate; With hydrogenchloride; In ethanol; water; at 70 - 80 ℃;

With hydrogenchloride; In ethanol; water;

DOI:10.1021/jf402145u

Reference yield:

C27H29O16(1-)*Na(1+) → β-D-glucose (492-61-5) + kaempferol (520-18-3)

Guidance literature:

With hydrogenchloride; In water; at 90 ℃; for 5h;

DOI:10.1016/j.fitote.2019.104248

Reference yield:

C33H39O20(1-)*C2H6*Na(1+) → β-D-glucose (492-61-5) + L-rhamnose (6014-42-2) + kaempferol (520-18-3)

Guidance literature:

With hydrogenchloride; In water; at 90 ℃; for 5h;

DOI:10.1016/j.fitote.2019.104248

upstream raw materials:

Aromadendrin

astragalin

kaempferol 3-O-β-D-glucuronide

astragalin

Downstream raw materials:

5-hydroxy-3,4',7-trimethoxyflavone

pelargonidin chloride

dihydrokaempferol

3,5-dihydroxyphenol

Refernces

• 1、 Kovganko,Kashkan,Krivenok. "Bioactive compounds of the flora of belarus. 3.* Gymnocarpium dryopteris, a kaempferol source". . p. 16 - 18. Retrieved 2004.
• 2、 Zakharov et al.. "-". . . Retrieved 1971.
• 3、 Dungerdorzh,Petrenko. "-". . . Retrieved 1972.
• 4、 Chumbalov et al.. "-". . . Retrieved 1972.
• 5、 Medveda et al.. "-". . . Retrieved 1972.
• 6、 Guzhva, N. N.,Kazakov, A. L.,Dzhumyrko, S. F.,Sarkisov, L. S.. "FLAVONOIDS OF Astragalus lagurus". . p. 627 - 628. Retrieved 1984.
• 7、 Sosa,Percheron. "-". . p. 441,445. Retrieved 1970.
• 8、 Zurabishvili,Kemertelidze. "-". . . Retrieved 1971.
• 9、 Wang, Jingqiu,Fang, Xianying,Ge, Lin,Cao, Fuliang,Zhao, Linguo,Wang, Zhenzhong,Xiao, Wei. "Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol". . . Retrieved 2018.
• 10、 Abd El-Wahab, Mohammed F.,Abdalla, Ashraf N.,Mohammed, Abd El-Salam I.,Mohammed, Hamdoon A.,Ragab, Ehab A.,Shaheen, Usama. "Isolation, characterization, complete structural assignment, and anticancer activities of the methoxylated flavonoids from rhamnus disperma roots". . . Retrieved 2021/10/01.