mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II)

Base Information

• Chemical Name: mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II)
• CAS No.: 138614-14-9
• Molecular Formula: C₆₄H₅₉N₂O₄P₃Ru
• Molecular Weight: 1114.17
• Mol file: 138614-14-9.mol

Synonyms:mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II)

Chemical Property of mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II)

There total 2 articles about mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(1,5-cyclooctadiene)(1,3,5-cyclooctatriene)ruthenium + ethyl 2-cyanoacetate (105-56-6) + triphenylphosphine (603-35-0) → mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II) (138614-14-9)

Guidance literature:

In tetrahydrofuran; (N2); addn. of NCCH2CO2Et to Ru complex and PPh3 in THF, stirring (room temp., 45 h); filtration, recrystn. (benzene/hexane);

DOI:10.1039/a902860i

Reference yield: 44.0%

dihydridotetrakis(triphenylphosphine)ruthenium (27599-25-3,54083-06-6,19529-00-1) + ethyl 2-cyanoacetate (105-56-6) → mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II) (138614-14-9)

Guidance literature:

In tetrahydrofuran; byproducts: H2; room temp., 26 h;

DOI:10.1021/ja00155a008

Reference yield: 90.0%

hydrogenchloride (7647-01-0,15364-23-5) + mer-hydrido[[(ethoxycarbonyl)methyl]cyano](ethyl cyanoacetate)tris(triphenylphosphine)ruthenium(II) (138614-14-9) → Ru2Cl4(NCCH2COOC2H5)(P(C6H5)3)4*C4H8O

Guidance literature:

In tetrahydrofuran; byproducts: H2, ethyl cyanoacetate; stirring (room temp., 21 h), removal (vac.); recrystn. (THF/hexane);

DOI:10.1021/ja00155a008

upstream raw materials:

ethyl 2-cyanoacetate

triphenylphosphine

dihydridotetrakis(triphenylphosphine)ruthenium

Downstream raw materials:

RuHI(PPh₃)₃

ethyl 2-cyanoacetate

hydrido[[(ethoxycarbonyl)methyl]cyano]dicarbonylbis(triphenylphosphine)ruthenium(II)

Refernces

• 1、 Murahashi, Shun-Ichi,Naota, Takeshi,Taki, Hiroshi,Mizuno, Masahiko,Takaya, Hikaru,Komiya, Sanshiro,Mizuho, Yuji,Oyasato, Naohiko,Hiraoka, Makiko,Hirano, Masafumi,Fukuoka, Atsushi. "Ruthenium-catalyzed aldol and Michael reactions of nitriles. Carbon-carbon bond formation by α-C-H activation of nitriles". . p. 12436 - 12451. Retrieved 2007/10/03.