Cefuroxime sodium

Base Information

• Chemical Name: Cefuroxime sodium
• CAS No.: 56238-63-2
• Molecular Formula: C16H15N4NaO8S
• Molecular Weight: 446.38 .
• Hs Code.: 2941.90
• European Community (EC) Number: 260-073-1
• NCI Thesaurus Code: C47439
• RXCUI: 204144
• Mol file: 56238-63-2.mol

Synonyms:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-,monosodium salt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-,monosodium salt, [6R-[6a,7b(Z)]]-;640/359;Biociclin;Bioxima;Cefamar;Cefumax;Cefurex;Cefurin;Curocef;Curoxim;Duxima;Ipacef;Kefurox;Lampsporin;Medoxim;Novocef;Spectrazol;Ultroxim;Zinacef;

Chemical Property of Cefuroxime sodium

Chemical Property:

• Appearance/Colour: White Crystalline Solid
• Melting Point: 240-245 °C(dec)
• PKA: pKa (water): 2.5; (DMF): 5.1(at 25℃)
• PSA: 201.89000
• LogP: -0.84160
• Storage Temp.: 2-8°C
• Solubility.: Freely soluble in water, very slightly soluble in ethanol (96 per cent).
• Water Solubility.: Freely soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 8
• Exact Mass: 446.05082891
• Heavy Atom Count: 30
• Complexity: 804

Purity/Quality:

99.0% MIN ^*data from raw suppliers

Cefuroxime sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43-36/37/38-20/21/22
• Safety Statements: 22-36/37-45-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)[O-].[Na+]
• Recent EU Clinical Trials: Short course antibiotic treatment of Gram-negative bacteremia: A multicenter, randomized, non-blinded, non-inferiority interventional study
• Description: Cefuroxime sodium is marketed by Eli Lilly and Company under the trade name of Kefurox? and by Glaxo Limited under the trade name of Zinacef?. Cefuroxime sodium is an off-white to white amorphous powder. Cefuroxime sodium is an injectable second generation, semisynthetic, broad spectrum cephalosporin antibiotic with excellent activity in vitro, enhanced stability to many enterobacterial β-lactamases and favorable pharmacokinetic properties. It is used to treat a wide variety of bacterial infections. It is effective for treating meningitis, lower respiratory tract infections, urinary tract infections, gonorrhea, septicemia, skin and skin infections, bone and joint infections, and is approved for surgical prophylaxis.
• Uses: Cefuroxime Sodium Salt is an antibacterial.
• Therapeutic Function: Antibiotic
• Clinical Use: Cefuroxime (Zinacef) is the first of a series of α-methoximinoacyl–substituted cephalosporins that constitute most of thethird-generation agents available for clinical use. A syn alkoximinosubstituent is associated with β-lactamase stability in these cephalosporins.78 Cefuroxime is classified as a secondgenerationcephalosporin because its spectrum of antibacterialactivity more closely resembles that of cefamandole. It is,however, active against β-lactamase–producing strains thatare resistant to cefamandole, such as E. coli, K. pneumoniae,N. gonorrhoeae, and H. influenzae. Other important Gramnegativepathogens, such as Serratia, indole-positive Proteusspp., P. aeruginosa, and B. fragilis, are resistant.Cefuroxime is distributed throughout the body. It penetratesinflamed meninges in high enough concentrations tobe effective in meningitis caused by susceptible organisms.Three-times-daily dosing is required to maintain effectiveplasma levels for most sensitive organisms, such asNeisseria meningitidis, Streptococcus pneumoniae, and H.influenzae. It has a plasma half-life of 1.4 hours.