2,3,4-trimethyl-1H-indole

Base Information

• Chemical Name: 2,3,4-trimethyl-1H-indole
• CAS No.: 10299-63-5
• Molecular Formula: C11H13 N
• Molecular Weight: 159.2276
• Mol file: 10299-63-5.mol

Synonyms:Indole,2,3,4-trimethyl- (7CI,8CI); 2,3,4-Trimethylindole

Chemical Property of 2,3,4-trimethyl-1H-indole

Chemical Property:

• Vapor Pressure: 0.0017mmHg at 25°C
• Boiling Point: 303.1°C at 760 mmHg
• Flash Point: 129.9°C
• Density: 1.056g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4-trimethyl-1H-indole

There total 3 articles about 2,3,4-trimethyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,4-dimethyl-1H-indole (10299-61-3) + carbon dioxide (124-38-9,18923-20-1) → 4-methyl-2,3-dimethyl-1H-indole (10299-63-5)

Guidance literature:

With methanesulfonic acid; hydrogen; tris(acetylacetonato)ruthenium(III); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine]; In tetrahydrofuran; at 140 ℃; for 24h; Autoclave; Sealed tube;

DOI:10.1002/anie.201405779

Reference yield:

(3-methylphenyl)hydrazine hydrochloride (637-04-7) + butanone (78-93-3) → 4-methyl-2,3-dimethyl-1H-indole (10299-63-5)

Guidance literature:

(3-methylphenyl)hydrazine hydrochloride; With acetic acid; at 50 ℃; for 0.5h;

butanone; for 3h; Reflux;

DOI:10.1039/d0ob02103b

Reference yield:

→ 4-methyl-2,3-dimethyl-1H-indole (10299-63-5)

Guidance literature:

2,4-Dimethyl-indol in Ae., LiAlH4 in Ae. ;

DOI:10.1021/jo01348a051

upstream raw materials:

2,4-dimethyl-1H-indole

carbon dioxide

(3-methylphenyl)hydrazine hydrochloride

butanone

Refernces

• 1、 Li, Yuehui,Yan, Tao,Junge, Kathrin,Beller, Matthias. "Catalytic methylation of C-H bonds using CO2 and H2". supporting information. p. 10476 - 10480. Retrieved 2016/02/18.