2-[(4-bromophenyl)methyl]benzooxazole

Base Information

• Chemical Name: 2-[(4-bromophenyl)methyl]benzooxazole
• CAS No.: 76284-87-2
• Molecular Formula: C14H10BrNO
• Molecular Weight: 288.1393
• Hs Code.: 2934999090
• Mol file: 76284-87-2.mol

Synonyms:

Chemical Property of 2-[(4-bromophenyl)methyl]benzooxazole

Chemical Property:

• Vapor Pressure: 2.92E-06mmHg at 25°C
• Boiling Point: 400.5°Cat760mmHg
• Flash Point: 196°C
• PSA: 26.03000
• Density: 1.476g/cm³
• LogP: 4.18110

Purity/Quality:

99%min ^*data from raw suppliers

2-(4-Bromobenzyl)benzo[d]oxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(4-bromophenyl)methyl]benzooxazole

There total 9 articles about 2-[(4-bromophenyl)methyl]benzooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-bromo-4-ethenyl-benzene (2039-82-9) + 2-amino-phenol (95-55-6) → 2-(4-bromobenzyl)benzo[d]oxazole (76284-87-2)

Guidance literature:

With N-methylcyclohexylamine; sulfur; at 110 ℃; for 36h; Schlenk technique;

DOI:10.1021/acs.joc.1c01357

Reference yield: 72.0%

2-(4-Bromo-phenyl)-acetimidic acid methyl ester; hydrochloride (76284-86-1) + 2-amino-phenol (95-55-6) → 2-(4-bromobenzyl)benzo[d]oxazole (76284-87-2)

Guidance literature:

In chloroform; for 6h; Ambient temperature;

Reference yield: 52.0%

2-chloro-1,3-benzoxazole (615-18-9) + p-<(trimethylsilyl)methyl>bromobenzene (17095-20-4) → 2-(4-bromobenzyl)benzo[d]oxazole (76284-87-2)

Guidance literature:

With 18-crown-6 ether; cesium fluoride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.1c05764

upstream raw materials:

2-(4-Bromo-phenyl)-acetimidic acid methyl ester; hydrochloride

2-amino-phenol

2-(4-bromophenyl)-acetic acid

4-Bromophenylacetonitrile

Downstream raw materials:

2-(4-(benzo[d]oxazol-2-ylmethyl)phenethyl)-4,6-dihydroxybenzoic acid

2-(4-ethynylbenzyl)benzo[d]oxazole

benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

Refernces

• 1、 Chen, Xuecheng,Han, Shiqing,Hu, Liang,Liu, Yafei,Luo, Yue,Pan, Bin,Peng, Yalan,Zhang, Jun,Zhang, Yurong. "Elemental Sulfur-Promoted Benzoxazole/Benzothiazole Formation Using a C=C Double Bond as a One-Carbon Donator". . p. 14485 - 14492. Retrieved 2021/11/12.
• 2、 Fan, Xuesen,He, Yan,Zhang, Xinying,Guo, Shenghai,Wang, Yangyang. "Synthesis of heteroaryl ketones via tandem reaction of 1,1-dibromoethenes". experimental part. p. 6369 - 6374. Retrieved 2011/09/12.