(+)-(2S,5S)-2,5-dimethylpiperazine

Base Information

• Chemical Name: (+)-(2S,5S)-2,5-dimethylpiperazine
• CAS No.: 59573-44-3
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.191
• Mol file: 59573-44-3.mol

Synonyms:(+)-(2S,5S)-2,5-dimethylpiperazine

Chemical Property of (+)-(2S,5S)-2,5-dimethylpiperazine

Chemical Property:

Purity/Quality:

95-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-(2S,5S)-2,5-dimethylpiperazine

There total 3 articles about (+)-(2S,5S)-2,5-dimethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(β-hydroxy-isopropyl)-(2-hydroxy-propyl)-amine (115893-42-0) + bis(2-hydroxy-1-methylethyl)amine (2294-46-4) + diisopropanolamine (110-97-4,1335-54-2) → (2S,6S)-2,6-dimethyl-piperazine (402832-69-3) + cis-2,6-dimethylpiperazine (21655-48-1,1013625-96-1) + 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) + (+)-(2S,5S)-2,5-dimethylpiperazine (59573-44-3)

Guidance literature:

With hydrogen; cobalt; In ammonia; at 200 ℃; for 3h; under 22502.3 Torr;

Reference yield:

2,5-dimethyl-pyrazine (123-32-0) → 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) + (+)-(2S,5S)-2,5-dimethylpiperazine (59573-44-3)

Guidance literature:

With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H₂O); hydrogen; 6,6′‐dihydroxyl‐2,2′‐bipyridine; In para-xylene; water; at 110 ℃; for 20h; Reagent/catalyst; Schlenk technique;

DOI:10.1002/anie.201705452

Reference yield:

2,5-dimethylpiperazine (106-55-8) → 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) + (+)-(2S,5S)-2,5-dimethylpiperazine (59573-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H₂O) / para-xylene / 20 h / Reflux; Inert atmosphere; Schlenk technique

2: Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H₂O); hydrogen; 6,6′‐dihydroxyl‐2,2′‐bipyridine / para-xylene; water / 20 h / 110 °C / Schlenk technique

With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H₂O); hydrogen; 6,6′‐dihydroxyl‐2,2′‐bipyridine; In para-xylene; water;

DOI:10.1002/anie.201705452

upstream raw materials:

(β-hydroxy-isopropyl)-(2-hydroxy-propyl)-amine

bis(2-hydroxy-1-methylethyl)amine

diisopropanolamine

2,5-dimethylpiperazine

Downstream raw materials:

(2S,5S)-1,4-dibenzoyl-2,5-dimethylpiperazine

Refernces

• 1、 -. "Process for preparing Cis-2,6-dimethylpiperazine". Example 2. . Retrieved 2008/06/13.