C₆₆H₈₈N₁₀

Base Information

• Chemical Name: C₆₆H₈₈N₁₀
• CAS No.: 1369968-55-7
• Molecular Formula: C₆₆H₈₈N₁₀
• Molecular Weight: 1021.49
• Mol file: 1369968-55-7.mol

Synonyms:C₆₆H₈₈N₁₀

Chemical Property of C₆₆H₈₈N₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₆H₈₈N₁₀

There total 7 articles about C₆₆H₈₈N₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-iodo-2,6-bis(4-octyl-1H-pyrazol-1-yl)pyridine (1369968-48-8) + 4,4'-biphenyldiboronic acid (4151-80-8) → C66H88N10 (1369968-55-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 80 ℃; for 72h; Inert atmosphere;

DOI:10.1021/jo300050m

Reference yield:

2,6-bis(4-(octyl)-1-ynyl-1H-pyrazol-1-yl)isonicotinic acid (1369968-46-6) → C66H88N10 (1369968-55-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: oxalyl dichloride / tetrahydrofuran; dichloromethane / 4 h / 20 °C

2.1: sodium azide / water; acetone

3.1: benzene / 16 h / Reflux

4.1: potassium carbonate / methanol / 8 h

4.2: 2 h / Cooling with ice

5.1: iodine; potassium iodide; isopentyl nitrite / dichloromethane / 12 h / Inert atmosphere; Heating

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 72 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; oxalyl dichloride; iodine; sodium carbonate; potassium carbonate; potassium iodide; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone; benzene; 3.1: Curtius rearrangement / 6.1: Suzuki coupling;

DOI:10.1021/jo300050m

Reference yield:

2,6-bis(4-octyl-1H-pyrazol-1-yl)pyridin-4-amine (1369968-47-7) → C66H88N10 (1369968-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; potassium iodide; isopentyl nitrite / dichloromethane / 12 h / Inert atmosphere; Heating

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 72 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium carbonate; potassium iodide; isopentyl nitrite; In 1,4-dioxane; dichloromethane; 2: Suzuki coupling;

DOI:10.1021/jo300050m

upstream raw materials:

ethyl 2,6-bis(4-octyl-1H-pyrazol-1-yl)isonicotinate

2,6-bis(4-(octyl)-1-ynyl-1H-pyrazol-1-yl)isonicotinic acid

2,6-bis(4-octyl-1H-pyrazol-1-yl)pyridin-4-amine

4-iodo-2,6-bis(4-octyl-1H-pyrazol-1-yl)pyridine

Refernces