4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol

Base Information Edit

Chemical Name:4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol
CAS No.:138-65-8
Molecular Formula:C8H11 N O3
Molecular Weight:169.18
Hs Code.:2922509090
European Community (EC) Number:205-337-9,622-681-9
NSC Number:294898
UNII:K294OAI79V
DSSTox Substance ID:DTXSID20858964
Nikkaji Number:J28.478E
Wikidata:Q27087994
NCI Thesaurus Code:C62098
Pharos Ligand ID:NMF49CYDVUBP
Metabolomics Workbench ID:47880
ChEMBL ID:CHEMBL432
Mol file:138-65-8.mol

Synonyms:138-65-8;dl-Norepinephrine;4-(2-amino-1-hydroxyethyl)benzene-1,2-diol;dl-Arterenol;dl-Noradrenaline;Noradrenalin, dl-;1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-;(+-)-Noradrenaline;NSC 294898;Norepinephrine, DL-;(+/-)-noradrenaline;EINECS 205-337-9;Levarterenol;L-Noradrenaline;UNII-K294OAI79V;[3H]NE;K294OAI79V;CHEBI:33569;NSC294898;NSC-294898;(1)-4-(2-Amino-1-hydroxyethyl)pyrocatechol;d-Arterenol;1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (+-)-;1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (.+/-.)-;BENZYL ALCOHOL, alpha-(AMINOMETHYL)-3,4-DIHYDROXY-, (+-)-;Noradrop;xi-Norepinephrine;Noradrenaline,(+);(+/-)-norepinephrine;(.+-.)-Noradrenaline;(.+/-.)-Arterenol;(.+-.)-Norepinephrine;DL-[7-3H]norepinephrine;(.+/-.)-Noradrenaline;CHEMBL432;D06GJW;(.+/-.)-Norepinephrine;WLN: Z1YQR CQ DQ;SCHEMBL2610;NORADRENALINE DL FORM;Norepinephrine, (+)-Isomer;GTPL484;Norepinephrine, (+,-)-Isomer;C(O)(CN)c1ccc(O)c(O)c1;BDBM35234;DTXSID20858964;NORADRENALINE, (+/-)-;BCP04227;NOREPINEPHRINE DL-FORM [MI];1, 4-(2-amino-1-hydroxyethyl)-;4-(1-Hydroxy-2-aminoethyl)catechol;PDSP1_001514;PDSP2_001498;AKOS000123495;AKOS022180874;CCG-204148;HR-0338;SDCCGSBI-0050041.P003;NCGC00185992-01;NCGC00185992-02;1-(3,4-Dihydroxy)phenyl-2-aminoethanol;AC-10030;Benzyl alcohol,4-dihydroxy-, (.+-.)-;LS-42677;LS-42678;FT-0603221;FT-0658803;FT-0679201;(+-)-4-(2-amino-1-hydroxyethyl)pyrocatechol;4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol;EN300-245335;1, 4-(2-amino-1-hydroxyethyl)-, (.+-.)-;4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol #;L000933;SR-01000075279-3;4-[(1rs)-2-amino-1-hydroxyethyl]-1,2-benzenediol;Q27087994;1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (dl)-;1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (RS)-;1,2-BENZENEDIOL, 4-(2-AMINO-1-HYDROXYETHYL)-, (+/-)-;Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (.+/-.)-;DL-Arterenol, dl-Norepinephrine, EINECS 205-337-9, (+/-)-Noradrenaline;104655-07-4

Suppliers and Price of 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
DL-NORADRENALINE 95.00%
5G
$ 1091.48

Total 56 raw suppliers

Chemical Property of 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol Edit

Chemical Property:

Vapor Pressure:1.3E-08mmHg at 25°C
Melting Point:~190 °C (dec.)
Refractive Index:1.659
Boiling Point:442.6 °C at 760 mmHg
PKA:9.57±0.10(Predicted)
Flash Point:221.5 °C
PSA：86.71000
Density:1.397 g/cm³
LogP:0.79020
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
XLogP3:-1.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:169.07389321
Heavy Atom Count:12
Complexity:142

Purity/Quality:

99% ^*data from raw suppliers

DL-NORADRENALINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s): T+
Hazard Codes:T+
Statements: 28-41-26/27/28
Safety Statements: 28-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(CN)O)O)O
Uses (±)-Noradrenaline is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.

Technology Process of 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol

There total 24 articles about 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.4%

: 104819-57-0,104873-30-5,104873-31-6
R,S-2,2'-dinitrobiphenyl-6,6'-dicarbonsaeure-di-N,N'-1-(3,4-dihydroxyphenyl)-1-hydroxy-2-amido-ethan

: 138-65-8
Norepinephrine

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 6h; Ambient temperature;
DOI:10.1016/S0040-4020(01)87372-5

Reference yield:

: 1-(3,4-dihydroxy-phenyl)-2-nitro-ethanone

: 138-65-8
Norepinephrine

: 499-61-6
arterenone

Guidance literature:: bei der Reduktion;

Reference yield:

: 5090-29-9
1-(3,4-dihydroxyphenyl)-1-oxo-2-amino-ethan-hydrochlorid

: 138-65-8
Norepinephrine

Guidance literature:: Multi-step reaction with 3 steps

1: 58.5 percent / NaHCO₃ / benzene; H₂O / 30 h

2: 74 percent / NaBH₄ / methanol / 24 h

3: 51.4 percent / H₂, conc HCl / Pd/C / ethanol / 6 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; ethanol; water; benzene;
DOI:10.1016/S0040-4020(01)87372-5