C₁₉H₂₃N₂F

Base Information

• Chemical Name: C₁₉H₂₃N₂F
• CAS No.: 915953-62-7
• Molecular Formula: C₁₉H₂₃FN₂
• Molecular Weight: 298.403
• Mol file: 915953-62-7.mol

Synonyms:C₁₉H₂₃N₂F

Chemical Property of C₁₉H₂₃N₂F

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₃N₂F

There total 1 articles about C₁₉H₂₃N₂F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

6-fluoroindoline (2343-23-9) + N,N-dimethyl-3-hydroxy-3-phenylpropylamine (5554-64-3) → C19H23N2F (915953-62-7)

Guidance literature:

N,N-dimethyl-3-hydroxy-3-phenylpropylamine; With methanesulfonyl chloride; triethylamine; In acetonitrile; at 20 ℃; for 3h;

6-fluoroindoline; With potassium carbonate; at 20 ℃; for 14h; Further stages.;

DOI:10.1016/j.bmc.2006.08.039

Reference yield: 75.0%

C19H23N2F (915953-62-7) → C19H21N2F (915953-71-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 0.5h; Heating;

DOI:10.1016/j.bmc.2006.08.039

Reference yield:

C19H23N2F (915953-62-7) → C18H19N2F

Guidance literature:

Multi-step reaction with 3 steps

1.1: 75 percent / manganese(IV) oxide / CH₂Cl₂ / 0.5 h / Heating

2.1: 1-chloroethyl chloroformate; diisopropylethylamine / CH₂Cl₂ / 2 h / 20 °C

2.2: methanol / 3 h / Heating

3.1: optical resolution by chiral HPLC

With manganese(IV) oxide; carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.bmc.2006.08.039

upstream raw materials:

6-fluoroindoline

N,N-dimethyl-3-hydroxy-3-phenylpropylamine

Downstream raw materials:

C₁₉H₂₁N₂F

C₁₈H₁₉FN₂

Refernces