2-Formylpyridine thiosemicarbazone

Base Information

• Chemical Name: 2-Formylpyridine thiosemicarbazone
• CAS No.: 3608-75-1
• Molecular Formula: C7H8 N4 S
• Molecular Weight: 180.233
• Hs Code.: 2933990090
• European Community (EC) Number: 660-925-6
• DSSTox Substance ID: DTXSID001272303
• Mol file: 3608-75-1.mol

Synonyms:2-formylpyridine thiosemicarbazone;2-formylpyridine thiosemicarbazone, (E)-isomer;2-formylpyridine thiosemicarbazone, (Z)-isomer;2-formylpyridine thiosemicarbazone, monohydrochloride;Pyr-2-CTS;pyridine-2-carboxaldehyde thiosemicarbazone

Chemical Property of 2-Formylpyridine thiosemicarbazone

Chemical Property:

• Vapor Pressure: 5.74E-05mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 346.5°Cat760mmHg
• Flash Point: 163.3°C
• PSA: 95.39000
• Density: 1.32g/cm³
• LogP: 1.33990
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 180.04696745
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-[(E)-2-pyridinylmethylidene]-1-hydrazinecarbothioamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C=NNC(=S)N

Technology Process of 2-Formylpyridine thiosemicarbazone

There total 7 articles about 2-Formylpyridine thiosemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

pyridine-2-carbaldehyde (1121-60-4) + thiosemicarbazide (79-19-6) → pyridine-2-carbaldehyde thiosemicarbazone (3608-75-1)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 100 ℃; for 5h;

DOI:10.1080/00958972.2014.936859

Reference yield:

α-picoline (109-06-8) + thiosemicarbazide (79-19-6) → pyridine-2-carbaldehyde thiosemicarbazone (3608-75-1)

Guidance literature:

With sodium tetrasulfide; at 110 ℃;

Reference yield:

N-benzenesulfonyl-N'-(pyridine-2-carbonyl)-hydrazine (300395-43-1) + thiosemicarbazide (79-19-6) → pyridine-2-carbaldehyde thiosemicarbazone (3608-75-1)

Guidance literature:

With sodium carbonate; glycerol;

upstream raw materials:

α-picoline

thiosemicarbazide

pyridine-2-carbaldehyde

N-benzenesulfonyl-N'-(pyridine-2-carbonyl)-hydrazine

Downstream raw materials:

pyridine-2-carbaldehyde-(2-methyl thiosemicarbazone)

pyridine-2-carbaldehyde-(2,S-dimethyl-iso thiosemicarbazone)

Cu⁽²⁺⁾*CH₃COO^(1-)*C₅H₄NCHNNCSNH₂^(1-)={Cu(CH₃COO)(C₇H₇N₄S)}

triphenylantimony(V) dichloride - 2-pyridinecarboxaldehyde thiosemicarbazone

Refernces

• 1、 Habibi, Alireza,Sadat Shandiz, Seyed Ataollah,salehzadeh, Ali,Moradi-Shoeili, Zeinab. "Novel pyridinecarboxaldehyde thiosemicarbazone conjugated magnetite nanoparticulates (MNPs) promote apoptosis in human lung cancer A549 cells". . p. 13 - 22. Retrieved 2020.
• 2、 Qi, Jinxu,Liang, Shichu,Gou, Yi,Zhang, Zhenlei,Zhou, Zuping,Yang, Feng,Liang, Hong. "Synthesis of four binuclear copper(II) complexes: Structure, anticancer properties and anticancer mechanism". . p. 360 - 368. Retrieved 2015.
• 3、 Chu, Yong,Jiang, Ming,Li, Wenjuan,Liang, Hong,Sun, Hongbin,Yang, Feng,Yang, Tongfu,Zhang, Zhenlei. "Developing a Novel Indium(III) Agent Based on Liposomes to Overcome Cisplatin-Induced Resistance in Breast Cancer by Multitargeting the Tumor Microenvironment Components". . p. 14587 - 14602. Retrieved 2021/10/25.
• 4、 Evren, Asaf Evrim,Yurtta?, Leyla,Ekselli, Bü?ra,Aksoy, Onur,Akalin-?ift?i, Gül?en. "Design and efficient synthesis of novel 4,5-dimethylthiazole-hydrazone derivatives and their anticancer activity". . p. 372 - 386. Retrieved 2021/06/17.