5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate

Base Information

• Chemical Name: 5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate
• CAS No.: 1373875-31-0
• Molecular Formula: C₂₀H₁₇NO₂
• Molecular Weight: 303.36
• Mol file: 1373875-31-0.mol

Synonyms:5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate

Chemical Property of 5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate

There total 6 articles about 5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(4-methylphenyl)pyridine (4467-06-5) + 1-methyl-2-vinyl-benzene (611-15-4) → 5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate (1373875-31-0)

Guidance literature:

With tert.-butylhydroperoxide; copper diacetate; In decane; chlorobenzene; at 120 ℃; for 13h;

DOI:10.1021/ol500224e

Reference yield: 64.0%

2-(4-methylphenyl)pyridine (4467-06-5) + bis(2-methylbenzyl) ether (16814-26-9) → 5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate (1373875-31-0)

Guidance literature:

With tert.-butylhydroperoxide; copper diacetate; In water; chlorobenzene; at 120 ℃; for 21h;

DOI:10.1039/c5ra03462k

Reference yield: 63.0%

ortho-methylbenzylamine (89-93-0) + 2-(4-methylphenyl)pyridine (4467-06-5) → 5-methyl-2-( pyridin-2-yl)phenyl 2-methylbenzoate (1373875-31-0)

Guidance literature:

With tert.-butylhydroperoxide; copper diacetate; In chlorobenzene; at 120 ℃; for 15h;

DOI:10.1039/c4ra09922b

upstream raw materials:

ortho-methylbenzoic acid

2-(4-methylphenyl)pyridine

1-methyl-2-vinyl-benzene

ortho-methylbenzylamine

Refernces

• 1、 Yedage, Subhash L.,Bhanage, Bhalchandra M.. "Amides and Ethers as Chemoselective Surrogates for Copper(II)-Catalyzed ortho Benzoyloxylation of 2-Phenylpyridines". . p. 2161 - 2169. Retrieved 2015/09/15.
• 2、 Behera, Ahalya,Rout, Saroj K.,Guin, Srimanta,Patel, Bhisma K.. "Benzylamine as an arylcarboxy surrogate: A copper catalysed o-benzoxylation of 2-phenylpyridines using benzyl amines". . p. 55115 - 55118. Retrieved 2015/01/16.